Synthesis and characterization of potential impurities of ezetimibe

被引：0

作者：

Satheesh, Deekonda ^{[1
,2
]}

Devi, Dharmasoth Rama ^{[3
]}

Basavaiah, Keloth ^{[2
]}

Sreenivasulu, B. ^{[1
]}

Reddy, Bhavanam Sekhara ^{[1
]}

Aegurla, Balakrishna ^{[1
]}

Kumar, Pallerla Satish ^{[1
]}

Guduri, Anil Kumar ^{[1
]}

Chavakula, Ramadas ^{[1
]}

机构：

[1] Aurobindo Pharma Ltd, Chem Res Dept, APL Res Ctr 2, Sangareddy 502329, Telangana, India

[2] Andhra Univ, AU Coll Sci & Technol, Dept Inorgan & Analyt Chem, Visakhapatnam, Andhra Pradesh, India

[3] Dr Sameoul George Inst Pharmaceut Sci, Markapur, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2023年 / 60卷 / 02期

关键词：

API; ezetimibe; des-fluoro aniline analog; ICH; m-fluoro aniline analog; o-fluorobenzene isomer; related substances; REDUCTION; MECHANISM; KETONES;

D O I：

10.1002/jhet.4584

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ezetimibe is an azetidinone derivative and a substituted beta-lactam, it is a hypolipidemic agent, and a drug substance that lowers the cholesterol levels in our body. The present work describes the origin, synthesis, and characterization of three impurities of ezetimibe, which are also positional isomers and/or related substances of ezetimibe. viz: o-Fluoro benzene isomer, m-Fluoro aniline analog, and des-fluoro aniline analogs of ezetimibe.

引用

页码：318 / 326

页数：9

共 50 条

[31] Green synthesis, characterization and potential application of reduced graphene oxide
Coros, Maria
Pogacean, Florina
Turza, Alexandru
Dan, Monica
Berghian-Grosan, Camelia
Pana, Ioan-Ovidiu
Pruneanu, Stela
PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES, 2020, 119
[32] Synthesis and Characterization of Template-Free VS4 Nanostructured Materials with Potential Application in Photocatalysis
Lui, Gregory
Jiang, Gaopeng
Duan, Aoshu
Broughton, Josh
Zhang, Jason
Fowler, Michael W.
Yu, Aiping
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2015, 54 (10) : 2682 - 2689
[33] Solid-state characterization and dissolution properties of ezetimibe–cyclodextrins inclusion complexes
R. Patel
D. Bhimani
J. Patel
D. Patel
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2008, 60 : 241 - 251
[34] In silico and in vitro evaluation of the potential genotoxic impurities of vildagliptin
Hamitoglu, Muhammed
Tugcu, Gulcin
Kilic, Ayse Gokcen
Esen, Gulsah
Aydin, Ahmet
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2025,
[35] Risk assessment report of potential impurities in cetirizine dihydrochloride
Leistner, Adrian
Haerling, Stephan
Kreher, Joerg-Detlef
Becker, Ivonne
Jung, Dirk
Holzgrabe, Ulrike
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 189
[36] Synthesis of TRIP and Analysis of Phosphate Salt Impurities
Klussmann, Martin
Ratjen, Lars
Hoffmann, Sebastian
Wakchaure, Vijay
Goddard, Richard
List, Benjamin
SYNLETT, 2010, (14) : 2189 - 2192
[37] An assessment of the carcinogenic potential of ezetimibe using nonclinical data in a weight-of-evidence approach
Halleck, M.
Davis, H. R.
Kirschmeier, P.
Levitan, D.
Snyder, R. D.
Treinen, K.
MacDonald, J. S.
TOXICOLOGY, 2009, 258 (2-3) : 116 - 130
[38] The Effects of Ezetimibe on Surrogate Markers of Cholesterol Absorption and Synthesis in Japanese Patients with Dyslipidemia
Hiramitsu, Shinya
Ishiguro, Yoshiaki
Matsuyama, Hiroyuki
Yamada, Kenji
Kato, Kazuo
Noba, Manji
Uemura, Akihisa
Yoshida, Satoshi
Matsubara, Yoshiro
Kani, Atsushi
Hasegawa, Kazuo
Hishida, Hitoshi
Ozaki, Yukio
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2010, 17 (01) : 106 - 114
[39] Solid-state characterization and dissolution properties of ezetimibe-cyclodextrins inclusion complexes
Patel, R.
Bhimani, D.
Patel, J.
Patel, D.
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2008, 60 (3-4) : 241 - 251
[40] Characterization, Purity Determination and Decomposition Kinetics of Ezetimibe Under Non-Isothermal Conditions
Martins, Guilherme A. G.
Murakami, Fabio S.
Sangoi, Maximiliano S.
Todeschini, Vitor
Bernardi, Larissa S.
Oliveira, Paulo R.
CURRENT PHARMACEUTICAL ANALYSIS, 2019, 15 (04) : 327 - 332

← 1 2 3 4 5 →