Synthesis and characterization of potential impurities of ezetimibe

被引：0
|
作者：
Satheesh, Deekonda [1 ,2 ]
Devi, Dharmasoth Rama [3 ]
Basavaiah, Keloth [2 ]
Sreenivasulu, B. [1 ]
Reddy, Bhavanam Sekhara [1 ]
Aegurla, Balakrishna [1 ]
Kumar, Pallerla Satish [1 ]
Guduri, Anil Kumar [1 ]
Chavakula, Ramadas [1 ]
机构：
[1] Aurobindo Pharma Ltd, Chem Res Dept, APL Res Ctr 2, Sangareddy 502329, Telangana, India
[2] Andhra Univ, AU Coll Sci & Technol, Dept Inorgan & Analyt Chem, Visakhapatnam, Andhra Pradesh, India
[3] Dr Sameoul George Inst Pharmaceut Sci, Markapur, India
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2023年 / 60卷 / 02期
关键词：
API; ezetimibe; des-fluoro aniline analog; ICH; m-fluoro aniline analog; o-fluorobenzene isomer; related substances; REDUCTION; MECHANISM; KETONES;
D O I：
10.1002/jhet.4584
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ezetimibe is an azetidinone derivative and a substituted beta-lactam, it is a hypolipidemic agent, and a drug substance that lowers the cholesterol levels in our body. The present work describes the origin, synthesis, and characterization of three impurities of ezetimibe, which are also positional isomers and/or related substances of ezetimibe. viz: o-Fluoro benzene isomer, m-Fluoro aniline analog, and des-fluoro aniline analogs of ezetimibe.
引用
收藏
页码：318 / 326
页数：9
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