Synthesis and characterization of potential impurities of ezetimibe

被引：0

作者：

Satheesh, Deekonda ^{[1
,2
]}

Devi, Dharmasoth Rama ^{[3
]}

Basavaiah, Keloth ^{[2
]}

Sreenivasulu, B. ^{[1
]}

Reddy, Bhavanam Sekhara ^{[1
]}

Aegurla, Balakrishna ^{[1
]}

Kumar, Pallerla Satish ^{[1
]}

Guduri, Anil Kumar ^{[1
]}

Chavakula, Ramadas ^{[1
]}

机构：

[1] Aurobindo Pharma Ltd, Chem Res Dept, APL Res Ctr 2, Sangareddy 502329, Telangana, India

[2] Andhra Univ, AU Coll Sci & Technol, Dept Inorgan & Analyt Chem, Visakhapatnam, Andhra Pradesh, India

[3] Dr Sameoul George Inst Pharmaceut Sci, Markapur, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2023年 / 60卷 / 02期

关键词：

API; ezetimibe; des-fluoro aniline analog; ICH; m-fluoro aniline analog; o-fluorobenzene isomer; related substances; REDUCTION; MECHANISM; KETONES;

D O I：

10.1002/jhet.4584

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ezetimibe is an azetidinone derivative and a substituted beta-lactam, it is a hypolipidemic agent, and a drug substance that lowers the cholesterol levels in our body. The present work describes the origin, synthesis, and characterization of three impurities of ezetimibe, which are also positional isomers and/or related substances of ezetimibe. viz: o-Fluoro benzene isomer, m-Fluoro aniline analog, and des-fluoro aniline analogs of ezetimibe.

引用

页码：318 / 326

页数：9

共 50 条

[1] First synthesis and characterization of key stereoisomers related to Ezetimibe
Ren, Yun
Duan, Yan-Jun
Li, Ren-Jun
Deng, Yong
Hai, Li
Wu, Yong
CHINESE CHEMICAL LETTERS, 2014, 25 (08) : 1157 - 1160
[2] Physicochemical characterization of ezetimibe and its impurities
Filip, Katarzyna
Bankowski, Krzysztof
Sidoryk, Katarzyna
Zagrodzka, Joanna
Laszcz, Marta
Trzcinska, Kinga
Szyprowska, Anna
Cmoch, Piotr
Maruszak, Wioleta
JOURNAL OF MOLECULAR STRUCTURE, 2011, 991 (1-3) : 162 - 170
[3] First synthesis and characterization of SRR/RSS-Ezetimibe
Ren, Yun
Li, RenJun
Deng, Yong
Guan, Mei
Wu, Yong
Hai, Li
TETRAHEDRON LETTERS, 2013, 54 (48) : 6443 - 6446
[4] Identification, isolation and characterization of process related impurities in ezetimibe
Guntupalli, Srikanth
Ray, Uttam Kumar
Murali, N.
Gupta, P. Badrinadh
Kumar, Vundavilli Jagadeesh
Satheesh, D.
Islam, Aminul
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 88 : 385 - 390
[5] Potential Impurities of Tigecycline: Synthesis, Isolation, Characterization and In Vitro Pharmacological Evaluation
Sharavanan, Selliamman Palaniyandi Nallusamy
Venkatesan, Chidambaram Subramanian
Sathiyanarayanan, Singaram
Kabilan, Senthamaraikannan
CURRENT PHARMACEUTICAL ANALYSIS, 2020, 16 (06) : 730 - 742
[6] "Ghost peaks" of ezetimibe: Solution degradation products of ezetimibe in acetonitrile induced by alkaline impurities from glass HPLC vials
Jin, Jianyang
Wang, Zhiying
Lin, Jinsheng
Zhu, Wenquan
Gu, Chengzhen
Li, Min
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2017, 140 : 281 - 286
[7] Investigation of reduction process and related impurities in ezetimibe
Zhang, Dengfeng
Su, Jiangtao
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2015, 107 : 355 - 363
[8] RELATED SUBSTANCES BY HPLC METHOD FOR THE DETECTION AND EVALUATION OF IMPURITIES IN EZETIMIBE DRUG MATERIAL
Rapeti, Durgababu
Reddy, Gudibanda Chandra Sekhar
Narayanarao, Kapavarapu Maruthi Venkata
Shyamala, Pulipaka
Krishna, Rallabhandi Murali
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2021, 12 (01): : 217 - 225
[9] Ezetimibe potential in cardiology practice
Lyakishev, A. A.
Semenova, A. E.
Miklishanskaya, S. V.
Kukharchuk, V. V.
CARDIOVASCULAR THERAPY AND PREVENTION, 2010, 9 (07): : 86 - 89
[10] Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe
Zhu, Yijun
Pan, Jing
Zhang, Shunli
Liu, Zhenren
Ye, Deyong
Zhou, Weicheng
SYNTHETIC COMMUNICATIONS, 2016, 46 (20) : 1687 - 1693

← 1 2 3 4 5 →