Impact of Methylprednisolone Pulse on the Mortality of Patients With Acute Respiratory Distress Syndrome Secondary to COVID-19

被引：0

作者：

Sousa, Adrian ^{[1
,2
,3
]}

Lima, Olalla ^{[1
,2
,3
]}

Perez-Gonzalez, Alexandre ^{[1
]}

Araujo, Alejandro ^{[2
,3
]}

Longueira, Rebeca ^{[1
,2
,3
]}

Otero, Anton ^{[1
,2
]}

Nunez, Marta ^{[4
]}

Ramos, Cristina ^{[4
]}

Martinez-Lamas, Lucia ^{[5
]}

Crespo-Casal, Manuel ^{[1
,2
]}

Rubianes, Martin ^{[1
,2
]}

Perez-Rodriguez, Maria Teresa ^{[1
,2
,3
,6
]}

机构：

[1] Complexo Hosp Univ Vigo CHUVI, Dept Internal Med, Infect Dis Unit, SERGAS, Vigo, Spain

[2] Complexo Hosp Univ Vigo CHUVI, Internal Med Res Grp, SERGAS, Vigo, Spain

[3] Complexo Hosp Univ Vigo CHUVI, Galicia Hlth Res Inst IIS Galicia Sur, Grp Virol & Pathogenesis, SERGAS UVIGO, Vigo, Spain

[4] Complexo Hosp Univ Vigo CHUVI, Pneumol Dept, SERGAS, Vigo, Spain

[5] Complexo Hosp Univ Vigo CHUVI, Microbiol Dept, SERGAS, Vigo, Spain

[6] Complexo Hosp Univ Vigo, Hosp Alvaro Cunqueiro, Galicia Sur Hlth Res Inst, Internal Med Dept, Estr Clara Campoamor 341, Vigo 36212, Pontevedra, Spain

来源：

INFECTIOUS DISEASES IN CLINICAL PRACTICE | 2023年 / 31卷 / 06期

关键词：

SARS-CoV-2; COVID-19; methylprednisolone pulse; acute respiratory distress syndrome; mortality;

D O I：

10.1097/IPC.0000000000001296

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IntroductionCorticosteroids have been thoroughly used in the treatment of COVID-19. The aim of the study was to analyze the impact of methylprednisolone pulse on in-hospital mortality of patients with acute respiratory distress syndrome (ARDS) due to COVID-19.MethodsWe conducted a retrospective, single-center observational study. We selected adult patients admitted to the hospital with the diagnosis of COVID-19 between March and June 2020. Cox regression was used to identify the factors associated with in-hospital mortality.ResultsA total of 306 patients were analyzed. In-hospital crude mortality rate was 17%. Diabetes mellitus (hazard ratio [HR], 5.5; 95% confidence interval [CI], 1.40-4.55), dementia (HR, 7.7; 95% CI, 4.25-13.87) and ARDS (HR, 4.2; 95% CI, 2.34-7.46) were associated with in-hospital mortality. In patients with ARDS diagnosis, the only in-hospital mortality risk factor was dementia (HR, 5.2; 95% CI, 2.44-11.07), whereas methylprednisolone pulse was a protective factor (HR, 0.2; 95% CI, 0.09-0.63). In the follow-up, 40% of patients had some symptom related to COVID-19.ConclusionsMethylprednisolone pulse reduced the in-hospital mortality in patients with ARDS due to COVID-19. A high percentage of patients presented persistent symptoms in 90 days after the hospital discharge.

引用

页数：6

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