Identification of a score allowing the diagnosis of subclinical rejection in renal transplantation

被引：0
作者：
Brouard, Sophie [1 ,2 ]
Kerleau, Clarisse [1 ]
Giral, Magali [1 ]
Danger, Richard [1 ]
机构：
[1] Nantes Univ, Ctr Res Transplantat & Translat Immunol CR2TI, UMR 1064, ITUN,Inserm,CHU Nantes, Nantes, France
[2] LabEx IGO Immunotherapy Graft Oncol, F-44000 Nantes, France
来源：
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE | 2024年 / 208卷 / 02期
关键词：
Kidney transplantation; ectopic gene expression; Graft rejection; Biomarkers; Pharmacological; Antibodies; Living donors; OPERATIONAL TOLERANCE; PROTOCOL BIOPSIES; GENE-EXPRESSION; KIDNEY; SIGNATURE; BLOOD;
D O I：
10.1016/j.banm.2023.06.016
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Based on a combination of 6 blood genes associated with tolerance in renal transplantation, we showed that this score was decreased in patients developing anti-HLA or donor-specific antibodies. After validating this association on a multicenter cohort of 588 patients with matched biopsies one year post-transplant, we showed conversely a significant decrease of this score in patients with subclinical rejection. Considering this early rejection as associated with a poor prognosis of graft survival, we refined this score with only two genes, AKR1C3 and TCL1A, and 4 clinical parameters, and showed that it was able to identify patients at low risk of developing subclinical rejection. This score, validated by two techniques (PCR, NanoString) and on a second independent cohort of 447 patients, should make it possible to improve the follow-up of kidney transplanted patients. @2023 Academie nationale de medcine. Published by Elsevier Masson SAS. All rights reserved.
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收藏
页码：226 / 234
页数：9
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