Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma

被引：3

作者：

Nedal, Tonje Marie Vikene ^{[1
]}

Moen, Siv Helen ^{[1
,2
]}

Roseth, Ingrid Aass ^{[1
]}

Tryggestad, Synne Stokke ^{[1
]}

Aass, Kristin Roseth ^{[1
]}

Hov, Gunhild Garmo ^{[1
,3
]}

Hella, Hanne ^{[1
]}

Sponaas, Anne-Marit ^{[1
]}

Standal, Therese ^{[1
,4
]}

机构：

[1] Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Ctr Mol Inflammat Res, Dept Clin & Mol Med, Trondheim, Norway

[2] Nord Trondelag Hosp Trust, Dept Res, Levanger, Norway

[3] St Olavs Hosp, Dept Clin Chem, Trondheim, Norway

[4] St Olavs Hosp, Dept Hematol, Trondheim, Norway

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

关键词：

UNDETERMINED SIGNIFICANCE; MONOCLONAL GAMMOPATHY; RISK; ANTIGENS; THERAPY; CANCER;

D O I：

10.1038/s41598-024-54193-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Obesity is associated with an increased risk of developing multiple myeloma (MM). The molecular mechanisms causing this association is complex and incompletely understood. Whether obesity affects bone marrow immune cell composition in multiple myeloma is not characterized. Here, we examined the effect of diet-induced obesity on bone marrow immune cell composition and tumor growth in a Vk*MYC (Vk12653) transplant model of multiple myeloma. We find that diet-induced obesity promoted tumor growth in the bone marrow and spleen and reduced the relative number of T and B cells in the bone marrow. Our results suggest that obesity may reduce MM immune surveillance and thus may contribute to increased risk of developing MM.

引用

页数：7

共 45 条

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[45] Neoantigen vaccine-induced CD4 T cells confer protective immunity in a mouse model of multiple myeloma through activation of CD8 T cells against non-vaccine, tumor-associated antigens
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