Prognostic Value of Hematological Parameters in Oral Squamous Cell Carcinoma

被引:8
作者
Trevisani, Lorenzo Fernandes Moca [1 ]
Kulcsar, Isabelle Fernandes [2 ]
Kulcsar, Marco Aurelio Vamondes [3 ]
Dedivitis, Rogerio Aparecido [4 ]
Kowalski, Luiz Paulo [5 ]
Matos, Leandro Luongo [3 ,6 ]
机构
[1] Univ Sao Paulo, Fac Med, Programa Posgrad Anestesiol Ciencias Cirurg & Med, BR-01246903 Sao Paulo, Brazil
[2] Univ Sao Paulo, Fac Med, Inst Canc Estado Sao Paulo Icesp, BR-01246000 Sao Paulo, Brazil
[3] Univ Sao Paulo, Fac Med, Head & Neck Surg Dept, Inst Canc Estado Sao Paulo Icesp, BR-01246000 Sao Paulo, Brazil
[4] Univ Sao Paulo, Hosp Clin, Fac Med, Head & Neck Surg Dept, BR-01246000 Sao Paulo, Brazil
[5] Univ Sao Paulo, Fac Med, Head & Neck Surg Dept, BR-01246000 Sao Paulo, Brazil
[6] Fac Israelita Ciencias Saude Albert Einstein, BR-05652000 Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
oral squamous cell carcinoma; prognosis; RDW; TO-LYMPHOCYTE RATIO; DISTRIBUTION WIDTH; SURVIVAL OUTCOMES; CANCER; MORTALITY; PLATELET; HEAD; PREDICTOR; SURGERY; IMPACT;
D O I
10.3390/cancers15215245
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Introduction: Oral squamous cell carcinoma (OSCC) remains a significant public health concern. The variables utilized to determine appropriate treatment for this disease also represent its most unfavorable prognostic factors, with these parameters solely determined by the neoplasm and its behavior. However, a lack of well-established indices is evident in the literature that specifically relate to the patient and indicate a worse prognosis. Objective: To assess the prognostic impact of hematological indices in patients with OSCC. Methods: This retrospective cohort study included patients with oral squamous cell carcinoma (OSCC) who underwent curative-intent treatment. Treatment encompassed surgery, followed by adjuvant therapy, as necessary. Laboratory tests were conducted immediately prior to surgery, and demographic information was obtained from medical records. Results: The cohort comprised 600 patients, with 73.5% being male subjects. Adjuvant treatment was recommended for 60.3% of patients. Throughout the follow-up period, 48.8% of participants died. Univariate analysis indicated that perineural invasion, angiolymphatic invasion, pT4 tumors, lymph node metastases, extranodal extravasation, RDW > 14.3%, NLR (neutrophil-lymphocyte ratio) > 3.38, PLR (platelet-lymphocyte ratio) > 167.3, and SII (systemic inflammatory/immune response index) > 416.1 were factors associated with increased mortality. These threshold values were established through ROC curve analysis. In the multivariate analysis, angiolymphatic invasion (HR = 1.43; 95% CI: 1.076-1.925; p = 0.014), pT4a/b tumors (HR = 1.761; 95% CI: 1.327-2.337; p < 0.001), extranodal extravasation (HR = 1.420; 95% CI: 1.047-1.926; p = 0.024), and RDW (HR = 1.541; 95% CI: 1.153-2.056; p = 0.003) were identified as independent risk factors for decreased overall survival. Conclusions: RDW > 14.3% was proven to be a reliable parameter for assessing overall survival in patients with OSCC. Further studies are required to evaluate the clinical applicability of other hematological indices.
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页数:12
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