Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology

被引：8
作者：
Du, Juan [1 ]
Huang, Tianyi [1 ]
Zheng, Zhen [2 ]
Fang, Shuai [3 ]
Deng, Hongxia [4 ]
Liu, Kaitai [2 ]
机构：
[1] Ningbo Univ, Hlth Sci Ctr, Ningbo 315211, Zhejiang, Peoples R China
[2] Ningbo Univ, Affiliated Lihuili Hosp, Dept Radiat Oncol, Ningbo, Zhejiang, Peoples R China
[3] Ningbo Univ, Affiliated Hosp, Med Sch, Ningbo, Zhejiang, Peoples R China
[4] Ningbo Univ, Affiliated Lihuili Hosp, Ningbo, Zhejiang, Peoples R China
来源：
CELL COMMUNICATION AND SIGNALING | 2023年 / 21卷 / 01期
关键词：
tsRNAs; Digestive disease; Diagnosis; Prognosis; Biomarkers; RNA-DERIVED FRAGMENT; IRRITABLE-BOWEL-SYNDROME; GASTRIC-CANCER; COLORECTAL-CANCER; DIAGNOSTIC BIOMARKERS; PROMISING BIOMARKER; SIGNALING PATHWAYS; NONCODING RNAS; CELL-DEATH; IBS-D;
D O I：
10.1186/s12964-023-01341-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
tsRNAs are small non-coding RNAs originating from tRNA that play important roles in a variety of physiological activities such as RNA silencing, ribosome biogenesis, retrotransposition, and epigenetic inheritance, as well as involvement in cellular differentiation, proliferation, and apoptosis. tsRNA-related abnormalities have a significant influence on the onset, development, and progression of numerous human diseases, including malignant tumors through affecting the cell cycle and specific signaling molecules. This review introduced origins together with tsRNAs classification, providing a summary for regulatory mechanism and physiological function while dysfunctional effect of tsRNAs in digestive system diseases, focusing on the clinical prospects of tsRNAs for diagnostic and prognostic biomarkers.42xgK5myx7tkGUVq1U3uKqVideo Abstract
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