Ciprofloxacin-Induced Anaphylactic Reaction Followed by Negative Provocation Test in Response to Levofloxacin: A Case Report

被引:2
|
作者
Kurtov, Marija [1 ]
Kilic, Paula [2 ]
Ikic, Lucija [3 ]
Kurtov, Karlo [4 ]
Dorcic, Gordan [5 ]
Vodanovic, Marko [6 ]
Artukovic, Marinko [2 ,7 ]
Matijasevic, Marina Ikic [2 ,6 ]
机构
[1] Univ Hosp Sveti Duh, Dept Clin Pharmacol & Toxicol, Zagreb 10000, Croatia
[2] Univ Hosp Sveti Duh, Dept Clin Immunol Rheumatol & Pulmonol, Zagreb 10000, Croatia
[3] Univ Appl Hlth Sci, Dept Anat & Physiol, Zagreb 10000, Croatia
[4] Univ Hosp Merkur, Dept Nephrol & Dialysis, Zagreb 10000, Croatia
[5] Univ Hosp Sveti Duh, Dept Nephrol & Dialysis, Zagreb 10000, Croatia
[6] Univ Hosp Sveti Duh, Div Gastroenterol & Hepatol, Zagreb 10000, Croatia
[7] Univ Zagreb, Sch Med, Dept Internal Med, Zagreb 10000, Croatia
来源
MEDICINA-LITHUANIA | 2023年 / 59卷 / 10期
关键词
fluoroquinolones; cross-reactivity; allergy; ciprofloxacin; levofloxacin; drug provocation test; skin prick test; IMMEDIATE HYPERSENSITIVITY; CROSS-REACTIVITY; QUINOLONES; MOXIFLOXACIN; TOLERANCE;
D O I
10.3390/medicina59101784
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Fluoroquinolones are a commonly prescribed class of antibiotics due to their broad spectrum of antimicrobial activity, favorable pharmacokinetic properties, ability to switch from parenteral to oral administration, and global availability. After beta-lactams, they are the second most common antibiotic class associated with drug allergies. The mechanism of fluoroquinolone-induced hypersensitivity reactions has not yet been fully understood, so the true incidence of hypersensitivity reactions remains unknown. Cross-reactivity between fluoroquinolones has been the subject of conflicting and limited clinical research. Due to their similar chemical structure, some argue for close cross-reactivity within the group. However, recent studies have produced contradictory results. We present the case of a young patient who had an anaphylactic reaction to ciprofloxacin but was tolerant to levofloxacin, as determined via a skin prick test followed by a drug provocation test. Our findings support the notion that there is little cross-reactivity between fluoroquinolones. Consequently, exposure to another fluoroquinolone in a hospital setting may be beneficial, particularly for patients who lack adequate antibiotic alternatives. However, additional research on this subject is required.
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页数:6
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