Optical Imaging Opportunities to Inspect the Nature of Cytosolic Iron Pools

被引：2

作者：

Hider, Robert Charles ^{[1
,2
]}

Pourzand, Charareh ^{[2
,3
,4
]}

Ma, Yongmin ^{[5
]}

Cilibrizzi, Agostino ^{[1
,3
]}

机构：

[1] Kings Coll London, Inst Pharmaceut Sci, London SE1 9NH, England

[2] Univ Bath, Dept Life Sci, Bath BA2 7AY, England

[3] Univ Bath, Ctr Therapeut Innovat, Bath BA2 7AY, England

[4] Univ Bath, Ctr Bioengn & Biomed Technol, Bath BA2 7AY, England

[5] Taizhou Univ, Inst Adv Studies, Sch Pharmaceut & Chem Engn, 1139 Shifu Ave, Taizhou 318000, Peoples R China

来源：

MOLECULES | 2023年 / 28卷 / 18期

关键词：

labile iron pools; fluorescence; iron sensitive optical probes; near-infrared probes; imaging; LABILE IRON; CHELATABLE IRON; CELLULAR IRON; INTRACELLULAR IRON; FLUORESCENT-PROBE; MONOTHIOL GLUTAREDOXINS; OXIDATIVE STRESS; METAL-COMPLEXES; FERRIC IRON; GLUTATHIONE;

D O I：

10.3390/molecules28186467

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chemical nature of intracellular labile iron pools (LIPs) is described. By virtue of the kinetic lability of these pools, it is suggested that the isolation of such species by chromatography methods will not be possible, but rather mass spectrometric techniques should be adopted. Iron-sensitive fluorescent probes, which have been developed for the detection and quantification of LIP, are described, including those specifically designed to monitor cytosolic, mitochondrial, and lysosomal LIPs. The potential of near-infrared (NIR) probes for in vivo monitoring of LIP is discussed.

引用

页数：21

共 9 条

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