New perspectives in diabetic neuropathy

被引：110

作者：

Eid, Stephanie A. ^{[1
,2
]}

Rumora, Amy E. ^{[3
]}

Beirowski, Bogdan ^{[4
,5
]}

Bennett, David L. ^{[6
]}

Hur, Junguk ^{[7
]}

Savelieff, Masha G. ^{[7
]}

Feldman, Eva L. ^{[1
,2
]}

机构：

[1] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, NeuroNetwork Emerging Therapies, Ann Arbor, MI 48109 USA

[3] Columbia Univ, Dept Neurol, New York, NY 10032 USA

[4] Ohio State Univ, Wexner Med Ctr, Dept Neurol, Columbus, OH 43210 USA

[5] Ohio State Univ, Wexner Med Ctr, Neurosci Res Inst, Columbus, OH 43210 USA

[6] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford OX3 9DU, England

[7] Univ North Dakota, Dept Biomed Sci, Grand Forks, ND 58202 USA

来源：

NEURON | 2023年 / 111卷 / 17期

基金：

英国生物技术与生命科学研究理事会;

关键词：

ENDOPLASMIC-RETICULUM STRESS; INDUCED OXIDATIVE STRESS; DORSAL-ROOT GANGLIA; PERIPHERAL NEUROPATHY; SCHWANN-CELLS; MICROVASCULAR COMPLICATIONS; AXONAL REGENERATION; SENSORY NEURONS; MURINE MODEL; NERVE;

D O I：

10.1016/j.neuron.2023.05.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D), which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy (DPN), the most common microvas-cular complication, is length-dependent damage to peripheral nerves. DPN pathogenesis is complex, but, at its core, it can be viewed as a state of impaired metabolism and bioenergetics failure operating against the backdrop of long peripheral nerve axons supported by glia. This unique peripheral nerve anatomy and the injury consequent to T2D underpins the distal-to-proximal symptomatology of DPN. Earlier work focused on the impact of hyperglycemia on nerve damage and bioenergetics failure, but recent evidence additionally implicates contributions from obesity and dyslipidemia. This review will cover peripheral nerve anatomy, bio-energetics, and glia-axon interactions, building the framework for understanding how hyperglycemia and dyslipidemia induce bioenergetics failure in DPN. DPN and painful DPN still lack disease-modifying thera-pies, and research on novel mechanism-based approaches is also covered.

引用

页码：2623 / 2641

页数：19

共 209 条

[1] Prevalence and Characteristics of Painful Diabetic Neuropathy in a Large Community-Based Diabetic Population in the UK [J].

Abbott, Caroline A. ;

Malik, Rayaz A. ;

van Ross, Ernest R. E. ;

Kulkarni, Jai ;

Boulton, Andrew J. M. .

DIABETES CARE, 2011, 34 (10) :2220-2224

[2] Improvements in Diabetic Neuropathy and Nephropathy After Bariatric Surgery: a Prospective Cohort Study [J].

Adam, Safwaan ;

Azmi, Shazli ;

Ho, Jan H. ;

Liu, Yifen ;

Ferdousi, Maryam ;

Siahmansur, Tarza ;

Kalteniece, Alise ;

Marshall, Andrew ;

Dhage, Shaishav S. ;

Iqbal, Zohaib ;

D'Souza, Yvonne ;

Natha, Salim ;

Kalra, Philip A. ;

Donn, Rachelle ;

Ammori, Basil J. ;

Syed, Akheel A. ;

Durrington, Paul N. ;

Malik, Rayaz A. ;

Soran, Handrean .

OBESITY SURGERY, 2021, 31 (02) :554-563

[3] Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes [J].

Afshinnia, Farsad ;

Reynolds, Evan L. ;

Rajendiran, Thekkelnaycke M. ;

Soni, Tanu ;

Byun, Jaeman ;

Savelieff, Masha G. ;

Looker, Helen C. ;

Nelson, Robert G. ;

Michailidis, George ;

Callaghan, Brian C. ;

Pennathur, Subramaniam ;

Feldman, Eva L. .

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 2022, 9 (09) :1392-1404

[4] SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes [J].

Agarwal, Nitin ;

Taberner, Francisco J. ;

Rojas, Daniel Rangel ;

Moroni, Mirko ;

Omberbasic, Damir ;

Njoo, Christian ;

Andrieux, Alexandra ;

Gupta, Pooja ;

Bali, Kiran K. ;

Herpel, Esther ;

Faghihi, Faramarz ;

Fleming, Thomas ;

Dejean, Anne ;

Lechner, Stefan G. ;

Nawroth, Peter P. ;

Lewin, Gary R. ;

Kuner, Rohini .

NEURON, 2020, 107 (06) :1141-+

[5] Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes [J].

Aghanoori, Mohamad-Reza ;

Smith, Darrell R. ;

Shariati-Ievari, Shiva ;

Ajisebutu, Andrew ;

Nguyen, Annee ;

Desmond, Fiona ;

Jesus, Carlos H. A. ;

Zhou, Xiajun ;

Calcutt, Nigel A. ;

Aliani, Michel ;

Fernyhough, Paul .

MOLECULAR METABOLISM, 2019, 20 :149-165

[6] Type 2 diabetes [J].

Ahmad, Ehtasham ;

Lim, Soo ;

Lamptey, Roberta ;

Webb, David R. ;

Davies, Melanie J. .

LANCET, 2022, 400 (10365) :1803-1820

[7] Diabetic neuropathy in children and youth: New and emerging risk factors [J].

Akinci, Gulcin ;

Savelieff, Masha G. ;

Gallagher, Gary ;

Callaghan, Brian C. ;

Feldman, Eva L. .

PEDIATRIC DIABETES, 2021, 22 (02) :132-147

[8] Schwann Cell-Derived Exosomes Enhance Axonal Regeneration in the Peripheral Nervous System [J].

Alejandra Lopez-Verrilli, Maria ;

Picou, Frederic ;

Court, Felipe A. .

GLIA, 2013, 61 (11) :1795-1806

[9] Status of peripheral sodium channel blockers for non-addictive pain treatment [J].

Alsaloum, Matthew ;

Higerd, Grant P. ;

Effraim, Philip R. ;

Waxman, Stephen G. .

NATURE REVIEWS NEUROLOGY, 2020, 16 (12) :689-705

[10] A gain-of-function sodium channel β2-subunit mutation in painful diabetic neuropathy [J].

Alsaloum, Matthew ;

Estacion, Mark ;

Almomani, Rowida ;

Gerrits, Monique M. ;

Boenhof, Gidon J. ;

Ziegler, Dan ;

Malik, Rayaz ;

Ferdousi, Maryam ;

Lauria, Giuseppe ;

Merkies, Ingemar S. J. ;

Faber, Catharina G. ;

Dib-Hajj, Sulayman ;

Waxman, Stephen G. ;

de Greef, B. ;

Hoeijmakers, J. G. J. ;

Sopacua, M. ;

Smeets, H. J. M. ;

Vanoevelen, J. M. ;

Eijkenboom, I ;

Lindsey, P. ;

Almomani, R. ;

Taiana, M. ;

Marchi, M. ;

Lombardi, R. ;

Cazzato, D. ;

Boneschi, F. M. ;

Zauli, A. ;

Clarelli, F. ;

Santoro, S. ;

Lopez, I ;

Quattrini, A. ;

Cestele, S. ;

Chever, O. ;

Tavakoli, M. ;

Malik, R. ;

Kapetis, D. ;

Xenakis, M. N. ;

Mantegazza, M. ;

Battiato, F. ;

Strom, A. .

MOLECULAR PAIN, 2019, 15

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