The 2022 Assisi Think Tank Meeting: White paper on optimising radiation therapy for breast cancer

被引：4

作者：

Aristei, C. ^{[1
,2
]}

Kaidar-Person, O. ^{[3
]}

Boersma, L. ^{[4
]}

Leonardi, M. C. ^{[5
]}

Offersen, B. ^{[6
]}

Franco, P. ^{[7
,8
]}

Arenas, M. ^{[9
]}

Bourgier, C. ^{[10
]}

Pfeffer, R. ^{[11
]}

Kouloulias, V ^{[12
]}

Bolukbasi, Y. ^{[13
]}

Meattini, I ^{[14
,15
]}

Coles, C. ^{[16
]}

Luis, A. Montero ^{[17
]}

Masiello, V. ^{[18
]}

Palumbo, I. ^{[1
,2
]}

Morganti, A. G. ^{[19
,20
]}

Perrucci, E. ^{[21
]}

Tombolini, V. ^{[22
]}

Krengli, M. ^{[23
,24
]}

Marazzio, F. ^{[25
]}

Trigo, L.

Borghesi, S. ^{[26
]}

Ciabattoni, A. ^{[27
]}

Ratosa, I. ^{[28
,29
]}

Valentini, V. ^{[30
,31
]}

Poortmans, P. ^{[32
,33
]}

机构：

[1] Univ Perugia, Radiat Oncol Sect, Dept Med & Surg, I-06156 Perugia, Italy

[2] Perugia Gen Hosp, I-06156 Perugia, Italy

[3] Sheba Med Ctr, Breast Radiat Unit, Radiat Oncol, Ramat Gan, Israel

[4] Maastricht Univ, GROW Sch Oncol & Dev Biol, Med Ctr, Radiat Oncol Maastro, Maastricht, Netherlands

[5] IRCCS, IEO European Inst Oncol, Div Radiat Oncol, Milan, Italy

[6] Aarhus Univ Hosp, Danish Ctr Particle Therapy, Dept Expt Clin Oncol, Dept Oncol, Aarhus, Denmark

[7] Univ Piemonte Orientale, Depatment Translat Med, Novara, Italy

[8] Maggiore Carita Univ Hosp, Dept Radiat Oncol, Novara, Italy

[9] Univ Rovira I Virgili, Hosp Universitari St Hoan Reus, IISPV, Radiat Oncol Dept, Tarragona, Spain

[10] Univ Montpellier, ICM Val Aurelle, Radiat Oncol, Montpellier, France

[11] Tel Aviv & Ben Gur Univ, Oncol Inst, Med Sch, Assuta Med Ctr, Beer Sheva, Israel

[12] Natl & Kapodistrian Univ Athens, Med Sch, Dept Radiol 2, Radiotherapy Unit, Zografos, Greece

[13] Koc Univ, Fac Med, Dept Radiat Oncol, Istanbul, Turkiye

[14] Univ Florence, Dept Expt & Clin Biomed Sci M Serio, Thales, Italy

[15] Azienda Ospedaliero Univ Careggi, Oncol Dept, Radiat Oncol Unit, Florence, Italy

[16] Univ Cambridge, Dept Oncol, Cambridge, England

[17] Hosp Univ HM Sanchinarro, HM Hosp, Dept Radiat Oncol, Madrid, Spain

[18] Fdn Policlin Gemelli IRCSS Roma, Dipartimento Diagnost Immagini, Unita Operativa Radioterapia Oncolog, Radioterapia Oncolog Ematol, Rome, Italy

[19] Alma Mater Studiorum Univ Bologna, DIMES, Bologna, Italy

[20] Alma Mater Studiorum Bologna Univ, IRCCS Azienda Ospedaliero Univ Bologna, Radiat Oncol, Bologna, Italy

[21] Perugia Gen Hosp, Radiat Oncol Sect, Perugia, Italy

[22] Univ Roma La Sapienza, Dept Radiol Oncol & Pathol Sci, Radiat Oncol, Rome, Italy

[23] Univ Padua, Padua, Italy

[24] Ist Oncol Veneto IRCCS, Padua, Italy

[25] Inst Portugues Oncol Porto Francisco Gentil EPE, Dept Image & Radioncol, Serv Brachytherapy, Porto, Portugal

[26] Azienda USL Toscana Sud Est, Radiat Oncol Unit Arezzo Valdarno, Arezzo, Italy

[27] San Filippo Neri Hosp, Clin & Rehabil Cardiol Unit, ASL Rome 1, Rome, Italy

[28] Inst Oncol Ljubljana, Div Radiat Oncol, Ljubljana, Slovenia

[29] Univ Ljubljana, Fac Med, Ljubljana, Slovenia

[30] Univ Cattolica Sacro Cuore, Dipartimento Diagnost Immagini, Radioterapia Oncol & Ematol, Milan, Iran

[31] Fdn Policlin Gemelli IRCSS Roma, Rome, Iran

[32] Univ Antwerp, Fac Med & Hlth Sci, Antwerp, Belgium

[33] Fac Med & Hlth Sci, Iridium Kankernetwerk, Dept Radiat Oncol, Antwerp, Belgium

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2023年 / 187卷

关键词：

Breast cancer; Radiation therapy; Combined modality treatment; Immunotherapy; Re-irradiation in relapsed patients; 2ND CONSERVATIVE TREATMENT; TARGET VOLUME DELINEATION; PEMBROLIZUMAB PLUS CHEMOTHERAPY; ESTRO CONSENSUS GUIDELINE; NEOADJUVANT CHEMOTHERAPY; SURVIVAL OUTCOMES; INTERNAL MAMMARY; SENTINEL NODE; TUMOR EVENT; OPEN-LABEL;

D O I：

10.1016/j.critrevonc.2023.104035

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The present white paper, referring to the 4th Assisi Think Tank Meeting on breast cancer, reviews state-of-the-art data, on-going studies and research proposals. <70% agreement in an online questionnaire identified the following clinical challenges: 1: Nodal RT in patients who have a) 1-2 positive sentinel nodes without ALND (axillary lymph node dissection); b) cN1 disease transformed into ypN0 by primary systemic therapy and c) 1-3 positive nodes after mastectomy and ALND. 2. The optimal combination of RT and immunotherapy (IT), patient selection, IT-RT timing, and RT optimal dose, fractionation and target volume. Most experts agreed that RT-IT combination does not enhance toxicity. 3: Re-irradiation for local relapse converged on the use of partial breast irradiation after second breast conserving surgery. Hyperthermia aroused support but is not widely available. Further studies are required to finetune best practice, especially given the increasing use of re-irradiation.

引用

页数：16

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