Hyperlipidemia and Cardiovascular Risk in Children and Adolescents

被引：28

作者：

Mainieri, Francesca ^{[1
]}

La Bella, Saverio ^{[1
]}

Chiarelli, Francesco ^{[1
]}

机构：

[1] Univ G dAnnunzio, Dept Pediat, I-66100 Chieti, Italy

来源：

BIOMEDICINES | 2023年 / 11卷 / 03期

关键词：

atherosclerotic cardiovascular disease; cardiovascular risk; hyperlipidemia; dyslipidemia; atherosclerosis; lipid metabolism; children; adolescents; DENSITY-LIPOPROTEIN CHOLESTEROL; INTIMA-MEDIA THICKNESS; ASSOCIATION EXPERT PANEL; CORONARY-ARTERY-DISEASE; FAMILIAL HYPERCHOLESTEROLEMIA; YOUNG-ADULTS; PEDIATRIC-PATIENTS; HEART-DISEASE; SERUM-LIPIDS; SUBCLINICAL ATHEROSCLEROSIS;

D O I：

10.3390/biomedicines11030809

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Atherosclerotic cardiovascular disease (ASCVD) represents the major cause of morbidity and mortality worldwide. The onset of the atherosclerosis process occurs during childhood and adolescence, subsequently leading to the onset of cardiovascular disease as young adults. Several cardiovascular risk factors can be identified in children and adolescents; however, hyperlipidemia, in conjunction with the global obesity epidemic, has emerged as the most prevalent, playing a key role in the development of ASCVD. Therefore, screening for hyperlipidemia is strongly recommended to detect high-risk children presenting with these disorders, as these patients deserve more intensive investigation and intervention. Treatment should be initiated as early as possible in order to reduce the risk of future ASCVD. In this review, we will discuss lipid metabolism and hyperlipidemia, focusing on correlations with cardiovascular risk and screening and therapeutic management to reduce or almost completely avoid the development of ASCVD.

引用

页数：25

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