The metabolites of lactic acid bacteria: classification, biosynthesis and modulation of gut microbiota

被引：64

作者：

Tang, Huang ^{[1
,2
]}

Huang, Wanqiu ^{[1
,2
]}

Yao, Yu-Feng ^{[1
,2
,3
,4
,5
,6
,7
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Inst Med Sci, Dept Microbiol & Immunol, Lab Bacterial Pathogenesis,Sch Med, Shanghai 200025, Peoples R China

[3] Shanghai Ruijin Hosp, Dept Infect Dis, Shanghai 200025, Peoples R China

[4] Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China

[6] Shanghai Key Lab Emergency Prevent, Diag & Treatment Resp Infect Dis 20dz2261100, Shanghai, Peoples R China

[7] Shanghai Jiao Tong Univ, Shanghai Inst Immunol, Sch Med, Shanghai 200025, Peoples R China

来源：

MICROBIAL CELL | 2023年 / 10卷 / 03期

基金：

中国国家自然科学基金;

关键词：

metabolites; lactic acid bacteria; gut microbiota; immune system; LACTOBACILLUS-PLANTARUM; EXOPOLYSACCHARIDES; IDENTIFICATION; INFECTION; SYSTEM; TRACT; HOST; MICE;

D O I：

10.15698/mic2023.03.792

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lactic acid bacteria (LAB) are ubiquitous mi-croorganisms that can colonize the intestine and partici-pate in the physiological metabolism of the host. LAB can produce a variety of metabolites, including organic acids, bacteriocin, amino acids, exopolysaccharides and vita-mins. These metabolites are the basis of LAB function and have a profound impact on host health. The intestine is colonized by a large number of gut microorganisms with high species diversity. Metabolites of LAB can keep the balance and stability of gut microbiota through aiding in the maintenance of the intestinal epithelial barrier, re-sisting to pathogens and regulating immune responses, which further influence the nutrition, metabolism and behavior of the host. In this review, we summarize the metabolites of LAB and their influence on the intestine. We also discuss the underlying regulatory mechanisms and emphasize the link between LAB and the human gut from the perspective of health promotion.

引用

页码：49 / 62

页数：14

共 136 条

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