Endoplasmic Reticulum Stress in Elderly Patients with COVID-19: Potential of Melatonin Treatment

被引：5

作者：

Yiang, Giou-Teng ^{[1
,2
]}

Wu, Chia-Chao ^{[3
,4
]}

Lu, Chien-Lin ^{[5
]}

Hu, Wan-Chung ^{[6
]}

Tsai, Yi-Ju ^{[7
]}

Huang, Yiao-Mien ^{[8
]}

Su, Wen-Lin ^{[2
,9
]}

Lu, Kuo-Cheng ^{[3
,5
,10
]}

机构：

[1] Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Emergency Med, New Taipei 231, Taiwan

[2] Tzu Chi Univ, Sch Med, Hualien 970, Taiwan

[3] Triserv Gen Hosp, Natl Def Med Ctr, Dept Internal Med, Div Nephrol, Taipei 114, Taiwan

[4] Dept & Grad Inst Microbiol & Immunol, Natl Def Med Ctr, Taipei 114, Taiwan

[5] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Sch Med, Dept Med,Div Nephrol, New Taipei 24352, Taiwan

[6] Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Clin Pathol, New Taipei 231, Taiwan

[7] Fu Jen Catholic Univ, Grad Inst Biomed & Pharmaceut Sci, Coll Med, New Taipei 243, Taiwan

[8] Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Dent, New Taipei 231, Taiwan

[9] Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Internal Med, Div Pulm & Crit Care Med, New Taipei 231, Taiwan

[10] Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Med, Div Nephrol, New Taipei 231, Taiwan

来源：

VIRUSES-BASEL | 2023年 / 15卷 / 01期

关键词：

melatonin; COVID-19; aging; ER stress; unfolded protein response; SARS-CoV-2; PATTERN-RECOGNITION RECEPTORS; SARS-COV-2; INFECTION; TRANSCRIPTION FACTOR; NLRP3; INFLAMMASOME; IMMUNE-RESPONSES; INNATE IMMUNITY; CROSS-TALK; ACTIVATION; PERK; CELLS;

D O I：

10.3390/v15010156

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aging processes, including immunosenescence, inflammation, inflammasome formation, genomic instability, telomeric attrition, and altered autophagy, are involved in viral infections and they may contribute to increased pathophysiological responses to the SARS-CoV-2 infection in the elderly; this poses additional risks of accelerated aging, which could be found even after recovery. Aging is associated with oxidative damage. Moreover, SARS-CoV-2 infections may increase the production of reactive oxygen species and such infections will disturb the Ca++ balance via an endoplasmic reticulum (ER) stress-mediated unfolded protein response. Although vaccine development and anti-inflammation therapy lower the severity of COVID-19, the prevalence and mortality rates are still alarming in some countries worldwide. In this review, we describe the involvement of viral proteins in activating ER stress transducers and their downstream signals and in inducing inflammation and inflammasome formation. Furthermore, we propose the potential of melatonin as an ER stress modulator, owing to its antioxidant, anti-inflammatory, and immunoregulatory effects in viral infections. Considering its strong safety profile, we suggest that additive melatonin supplementation in the elderly could be beneficial in treating COVID-19.

引用

页数：22

共 173 条

[1] Melatonin as a potential modulator of Nrf2 [J].