Abdominal transplantation of pancreatic islets to protect against type 1 diabetes

被引：0
作者：
Sun, Shicheng [1 ]
Deng, Hongkui [1 ]
机构：
[1] Peking Univ, Beijing, Peoples R China
来源：
NATURE METABOLISM | 2023年 / 5卷 / 01期
关键词：
STEM-CELLS;
D O I：
10.1038/s42255-022-00714-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Human pluripotent stem cell-derived pancreatic islets (PSC-islets) hold promise in type I diabetes treatment, although their delivery is a challenge. We describe a new abdominal infusion transplantation protocol that enables the survival, maturation and maintenance of functional PSC-islets in diabetic monkeys.
引用
收藏
页码：19 / 20
页数：2
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  • [1] Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates
    Du, Yuanyuan
    Liang, Zhen
    Wang, Shusen
    Sun, Dong
    Wang, Xiaofeng
    Liew, Soon Yi
    Lu, Shuaiyao
    Wu, Shuangshuang
    Jiang, Yong
    Wang, Yaqi
    Zhang, Boya
    Yu, Wenhai
    Lu, Zhi
    Pu, Yue
    Zhang, Yun
    Long, Haiting
    Xiao, Shanshan
    Liang, Rui
    Zhang, Zhengyuan
    Guan, Jingyang
    Wang, Jinlin
    Ren, Huixia
    Wei, Yanling
    Zhao, Jiaxu
    Sun, Shicheng
    Liu, Tengli
    Meng, Gaofan
    Wang, Le
    Gu, Jiabin
    Wang, Tao
    Liu, Yinan
    Li, Cheng
    Tang, Chao
    Shen, Zhongyang
    Peng, Xiaozhong
    Deng, Hongkui
    [J]. NATURE MEDICINE, 2022, 28 (02) : 272 - +
  • [2] Chemical reprogramming of human somatic cells to pluripotent stem cells
    Guan, Jingyang
    Wang, Guan
    Wang, Jinlin
    Zhang, Zhengyuan
    Fu, Yao
    Cheng, Lin
    Meng, Gaofan
    Lyu, Yulin
    Zhu, Jialiang
    Li, Yanqin
    Wang, Yanglu
    Liuyang, Shijia
    Liu, Bei
    Yang, Zirun
    He, Huanjing
    Zhong, Xinxing
    Chen, Qijing
    Zhang, Xu
    Sun, Shicheng
    Lai, Weifeng
    Shi, Yan
    Liu, Lulu
    Wang, Lipeng
    Li, Cheng
    Lu, Shichun
    Deng, Hongkui
    [J]. NATURE, 2022, 605 (7909) : 325 - +
  • [3] Generation of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts
    Liu, Haisong
    Zhu, Fangfang
    Yong, Jun
    Zhang, Pengbo
    Hou, Pingping
    Li, Honggang
    Jiang, Wei
    Cai, Jun
    Liu, Meng
    Cui, Kai
    Qu, Xiuxia
    Xiang, Tingting
    Lu, Danyu
    Chi, Xiaochun
    Gao, Ge
    Ji, Weizhi
    Ding, Mingxiao
    Deng, Hongkui
    [J]. CELL STEM CELL, 2008, 3 (06) : 587 - 590
  • [4] Clinical pancreatic islet transplantation
    Shapiro, A. M. James
    Pokrywczynska, Marta
    Ricordi, Camillo
    [J]. NATURE REVIEWS ENDOCRINOLOGY, 2017, 13 (05) : 268 - 277
  • [5] Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.
    Shapiro, AMJ
    Lakey, JRT
    Ryan, EA
    Korbutt, GS
    Toth, E
    Warnock, GL
    Kneteman, NM
    Rajotte, RV
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (04) : 230 - 238
  • [6] Inducing embryonic stem cells to differentiate into pancreatic β cells by a novel three-step approach with activin A and all-trans retinoic acid
    Shi, Y
    Hou, LL
    Tang, FC
    Jiang, W
    Wang, PG
    Ding, MX
    Deng, HK
    [J]. STEM CELLS, 2005, 23 (05) : 656 - 662
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