Near-Infrared-Responsive Choline-Calix[4]arene-Gold Nanostructures for Potential Photothermal Cancer Treatment

被引：11

作者：

Consoli, Grazia M. L. ^{[4
,5
]}

Forte, Giuseppe ^{[1
]}

Maugeri, Ludovica ^{[1
]}

Consoli, Valeria ^{[1
]}

Sorrenti, Valeria ^{[1
]}

Vanella, Luca ^{[1
]}

Buscarino, Gianpiero ^{[2
]}

Agnello, Simonpietro ^{[2
]}

Camarda, Massimo ^{[3
]}

Granata, Giuseppe ^{[4
]}

Ferreri, Loredana ^{[4
]}

Petralia, Salvatore ^{[5
]}

机构：

[1] Univ Catania, Dept Drug Sci & Hlth, I-95125 Catania, Italy

[2] Univ Palermo, Dipartimento Fis & Chim, I-90133 Palermo, Italy

[3] ST Lab srl, I-95126 Catania, Italy

[4] CNR, Inst Biomol Chem, I-95126 Catania, Italy

[5] UO Catania, CIB Interuniv Consortium Biotechnol, I-34148 Trieste, Italy

来源：

ACS APPLIED NANO MATERIALS | 2023年 / 6卷 / 01期

关键词：

gold nanostructures; calixarene; photothermal effect; molecular modeling; photothermal therapy; cancer treatment; CAPPED GOLD NANOPARTICLES;

D O I：

10.1021/acsanm.2c04501

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The development of novel chemical approaches for the fabrication of gold nanostructures with localized surface plasmon resonance (LSPR) falling in the near-infrared (NIR) region is one challenging topic in nanomaterials science. Due to their optical and photothermal properties triggered by light excitation in the therapeutic window (Amax = 650-1300 nm), gold-based nanostructures are appealing candidates in anticancer nanomedicine. Here, we report a novel method to prepare waterdispersible gold nanostructures with NIR-LSPR (Amax = 600-1000 nm) properties. The gold nanostructures were achieved in a single step by an unconventional method using NADH as a reducing agent and an amphiphilic choline-calix[4]arene derivative (CholCalix) forming micelles as a template. The CholCalix-Au nanostructures were characterized by UV-visible spectrophotometry, Raman spectroscopy, and atomic force microscopy. Agglomeration of the nanostructures due to multiple crosslinking interactions was observed and supported by modeling simulation. Effective anticancer photothermal-induced effect of the CholCalix-AuNPs was demonstrated on human breast cancer cells irradiated with biofriendly light at 808 nm.

引用

页码：358 / 369

页数：12

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