Near-Infrared-Responsive Choline-Calix[4]arene-Gold Nanostructures for Potential Photothermal Cancer Treatment

被引：11

作者：

Consoli, Grazia M. L. ^{[4
,5
]}

Forte, Giuseppe ^{[1
]}

Maugeri, Ludovica ^{[1
]}

Consoli, Valeria ^{[1
]}

Sorrenti, Valeria ^{[1
]}

Vanella, Luca ^{[1
]}

Buscarino, Gianpiero ^{[2
]}

Agnello, Simonpietro ^{[2
]}

Camarda, Massimo ^{[3
]}

Granata, Giuseppe ^{[4
]}

Ferreri, Loredana ^{[4
]}

Petralia, Salvatore ^{[5
]}

机构：

[1] Univ Catania, Dept Drug Sci & Hlth, I-95125 Catania, Italy

[2] Univ Palermo, Dipartimento Fis & Chim, I-90133 Palermo, Italy

[3] ST Lab srl, I-95126 Catania, Italy

[4] CNR, Inst Biomol Chem, I-95126 Catania, Italy

[5] UO Catania, CIB Interuniv Consortium Biotechnol, I-34148 Trieste, Italy

来源：

ACS APPLIED NANO MATERIALS | 2023年 / 6卷 / 01期

关键词：

gold nanostructures; calixarene; photothermal effect; molecular modeling; photothermal therapy; cancer treatment; CAPPED GOLD NANOPARTICLES;

D O I：

10.1021/acsanm.2c04501

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The development of novel chemical approaches for the fabrication of gold nanostructures with localized surface plasmon resonance (LSPR) falling in the near-infrared (NIR) region is one challenging topic in nanomaterials science. Due to their optical and photothermal properties triggered by light excitation in the therapeutic window (Amax = 650-1300 nm), gold-based nanostructures are appealing candidates in anticancer nanomedicine. Here, we report a novel method to prepare waterdispersible gold nanostructures with NIR-LSPR (Amax = 600-1000 nm) properties. The gold nanostructures were achieved in a single step by an unconventional method using NADH as a reducing agent and an amphiphilic choline-calix[4]arene derivative (CholCalix) forming micelles as a template. The CholCalix-Au nanostructures were characterized by UV-visible spectrophotometry, Raman spectroscopy, and atomic force microscopy. Agglomeration of the nanostructures due to multiple crosslinking interactions was observed and supported by modeling simulation. Effective anticancer photothermal-induced effect of the CholCalix-AuNPs was demonstrated on human breast cancer cells irradiated with biofriendly light at 808 nm.

引用

页码：358 / 369

页数：12

共 67 条

[1] Gromacs: High performance molecular simulations through multi-level parallelism from laptops to supercomputers [J].

Abraham, Mark James ;

Murtola, Teemu ;

Schulz, Roland ;

Páll, Szilárd ;

Smith, Jeremy C. ;

Hess, Berk ;

Lindah, Erik .

SoftwareX, 2015, 1-2 :19-25

[2] Targeted anticancer therapy: Overexpressed receptors and nanotechnology [J].

Akhtar, Mohd Javed ;

Ahamed, Maqusood ;

Alhadlaq, Hisham A. ;

Alrokayan, Salman A. ;

Kumar, Sudhir .

CLINICA CHIMICA ACTA, 2014, 436 :78-92

[3] Biosensing with plasmonic nanosensors [J].

Anker, Jeffrey N. ;

Hall, W. Paige ;

Lyandres, Olga ;

Shah, Nilam C. ;

Zhao, Jing ;

Van Duyne, Richard P. .

NATURE MATERIALS, 2008, 7 (06) :442-453

[4]

Arunagirinathan M., 2012, MICROSC MICROANAL, V18, P1628

[5] Gold nanoparticles decorated by clustered multivalent cone-glycocalixarenes actively improve the targeting efficiency toward cancer cells [J].

Avvakumova, Svetlana ;

Fezzardi, Paola ;

Pandolfi, Laura ;

Colombo, Miriam ;

Sansone, Francesco ;

Casnati, Alessandro ;

Prosperi, Davide .

CHEMICAL COMMUNICATIONS, 2014, 50 (75) :11029-11032

[6] Gold nanoparticles in the clinical laboratory: principles of preparation and applications [J].

Azzazy, Hassan M. E. ;

Mansour, Mai M. H. ;

Samir, Tamer M. ;

Franco, Ricardo .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2012, 50 (02) :193-209

[7] Ultrasound-accelerated synthesis of gold nanoparticles modified choline chloride functionalized graphene oxide as a novel sensitive bioelectrochemical sensor: Optimized meloxicam detection using CCD-RSM design and application for human plasma sample [J].

Bahrani, Sonia ;

Razmi, Zahra ;

Ghaedi, Mehrorang ;

Asfaram, Arash ;

Javadian, Hamedreza .

ULTRASONICS SONOCHEMISTRY, 2018, 42 :776-786

[8] Role of gold nanoparticles in advanced biomedical applications [J].

Bansal, Suneev Anil ;

Kumar, Vanish ;

Karimi, Javad ;

Singh, Amrinder Pal ;

Kumar, Suresh .

NANOSCALE ADVANCES, 2020, 2 (09) :3764-3787

[9] Calixarene-Based Surfactants: Conformational-Dependent Solvation Shells for the Alkyl Chains [J].

Basilio, Nuno ;

Garcia-Rio, Luis .

CHEMPHYSCHEM, 2012, 13 (09) :2368-2376

[10]

Baymiller M., 2017, RAPID ONE STEP SYNTH, DOI [10.19185/matters.201705000007, DOI 10.19185/MATTERS.201705000007]

← 1 2 3 4 5 6 7 →