Overexpression of SATB1 correlates with epithelial-mesenchymal transition and lymphatic metastasis in gastric cancer

Background: Gastric cancer (GC) is a malignant tumor with a high mortality rate, and lymphatic metastasis is the main mode of GC metastasis. The nuclear transcriptional regulatory protein SATB1 has been confirmed to be closely related to GC metastasis, but the mechanism has not been elucidated.Methods: Epithelial-mesenchymal transition (EMT) is known as the pivotal process of GC metastasis. To evaluate the relationship between SATB1 and EMT in GC metastasis, the immunohistochemical method was used to detect the expression of SATB1, E-cadherin, N-cadherin, Vimentin protein in 52 paraffin-embedded specimens of gastric cancer, and analyze the relationship between their expression and pathological parameters.Results: Abnormal positive expression of SATB1 protein in paraffin-embedded tumor tissues was positively correlated with local invasion, lymph node metastasis, and TNM staging in gastric cancer. There was a statis-tically significant difference in the expression of SATB1 between the early stage of gastric cancer (stage I) and the advanced stage (stageII, III, IV). Moreover, SATB1 expression was positively correlated to N-cadherin and Vimentin but negatively to E-cadherin from Stages I to IV.Conclusion: The GC patients with overexpression of SATB1 tended to have advanced stage and lymph node metastasis. SATB1 was positively correlated with EMT in Gastric Cancer.