Case of bullous pemphigoid refractory to corticosteroids by antiepileptic drug-induced CYP3A4

被引：0

作者：

Asakawa, Riko ^{[1
]}

Ogawa, Youichi ^{[1
]}

Maejima, Eri ^{[1
]}

Honobe-Tabuchi, Akiko ^{[1
]}

Okamoto, Takashi ^{[1
]}

Mitsui, Hiroshi ^{[1
]}

Kagawa, Yoshiyuki ^{[2
]}

Shimada, Shinji ^{[1
]}

Kawamura, Tatsuyoshi ^{[1
]}

机构：

[1] Univ Yamanashi, Fac Med, Dept Dermatol, 1110 Shimokato, Chuo, Yamanashi 4093898, Japan

[2] Univ Shizuoka, Sch Pharmaceut Sci, Lab Clin Pharmaceut, Shizuoka, Japan

来源：

JOURNAL OF DERMATOLOGY | 2023年 / 50卷 / 02期

关键词：

antiepileptic drugs; bullous pemphigoid; corticosteroids; METABOLISM;

D O I：

10.1111/1346-8138.16624

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The most common treatment option for patients with bullous pemphigoid is systemic corticosteroids. CYP3A4, a drug-metabolizing enzyme in the liver, metabolizes synthetic steroids to a varying degree. Although there are many CYP3A4-inducing drugs, several antiepileptic drugs, such as phenytoin and phenobarbital, strongly induce CYP3A4, thereby reducing the effects of corticosteroids. Here, we report a case of refractory bullous pemphigoid that rapidly improved after the discontinuation of phenytoin and phenobarbital. To achieve adequate pharmacological effects of corticosteroids, we must always ensure that patients who require corticosteroids for treatment are not medicated with CYP3A4-inducing agents.

引用

页码：254 / 257

页数：4

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