Grade group 4 prostate cancer without intraductal carcinoma on biopsy is more likely to be downgraded on prostatectomy than with intraductal carcinoma

被引：1

作者：

Trabzonlu, Levent ^{[1
,2
]}

Chaiprasit, Thanchanok ^{[1
]}

Kontosis, Andreas ^{[1
]}

Picken, Maria ^{[1
]}

机构：

[1] Loyola Univ Med Ctr, Dept Pathol & Lab Med, Maywood, IL 60153 USA

[2] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

来源：

VIRCHOWS ARCHIV | 2024年 / 484卷 / 03期

关键词：

Prostate cancer; Intraductal carcinoma; Grade group 4; Downgrading; NEEDLE-BIOPSY; GLEASON; 8;

D O I：

10.1007/s00428-024-03745-4

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

In this study, we investigated the association between intraductal carcinoma of the prostate (IDCP) along with several histopathological features on prostate biopsy and downgrading of grade group 4 (GG4) prostate cancer (PCa) in patients with the highest grade tumor of GG4 PCa in at least one core. A total of 29 cases had the highest grade tumor of GG4 PCa and radical prostatectomy performed between 2016 and 2021. IDCP was detected in 11 out of 29 cases on biopsy. The cases without IDCP were more likely to be downgraded on prostatectomy than with IDCP, with statistical significance (88.9% vs 36.4%, p = 0.003). The proportions of the highest-grade tumors by length and cores involved, average numbers of PCa-positive cores, and mean patient's age did not differ between cases that were downgraded and not downgraded at prostatectomy. Our results suggest that the absence of IDCP on biopsy could be a predictor of downgrading at prostatectomy for patients with the highest grade tumor of GG4 PCa.

引用

页码：517 / 520

页数：4

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