Adipocytic Differentiation in a Sertoli Cell Tumor

被引：0
作者：
Molina, Jordan [1 ]
Dabaja, Ali [2 ]
Gupta, Nilesh [1 ,3 ]
Alruwaii, Fatimah I. [1 ]
Hassan, Oudai [1 ,3 ]
Al-Obaidy, Khaleel I. [1 ,3 ,4 ]
机构：
[1] Henry Ford Hlth, Dept Pathol & Lab Med, Detroit, MI USA
[2] Henry Ford Hlth, Dept Urol, Detroit, MI USA
[3] Michigan State Univ, Coll Human Med, Dept Med, E Lansing, MI USA
[4] Henry Ford Hlth, Dept Pathol & Lab Med, 2799W Grand Blvd, Detroit, MI 48202 USA
来源：
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2024年 / 32卷 / 06期
关键词：
testis; sex cord-stromal; Sertoli; Leydig; germ cell; TESTIS;
D O I：
10.1177/10668969231213983
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Testicular sex cord-stromal tumors are clonal neoplasms, with the majority being of Leydig cell followed by Sertoli cell origins. In Leydig cell tumors, adipocytic differentiation has been previously reported as a possible distinguishing feature, which has not been reported in other sex cord-stromal tumors. Herein, we report a case of a 48-year-old man who presented with an incidentally discovered 1.1 cm testicular mass, for which he underwent partial orchiectomy. Microscopically, the tumor showed features consistent with sex cord-stromal tumor with strong and diffuse nuclear and cytoplasmic reaction for B-catenin immunohistochemistry, supporting the diagnosis of Sertoli cell tumor. A novel adipocytic differentiation, reported previously in Leydig cell tumors, was present in this tumor.
引用
收藏
页码：1149 / 1153
页数：5
相关论文
共 13 条
  • [1] Current Treatment of Testicular Sex Cord-stromal Tumors: Critical Review
    Acar, Cenk
    Gurocak, Serhat
    Sozen, Sinan
    [J]. UROLOGY, 2009, 73 (06) : 1165 - 1171
  • [2] Appendageal tumors and tumor-like lesions of the testis and paratestis: a 32-year experience at a single institution
    Al-Obaidy, Khaleel, I
    Alruwaii, Fatimah, I
    Ulbright, Thomas M.
    Idrees, Muhammad T.
    [J]. HUMAN PATHOLOGY, 2020, 103 : 25 - 33
  • [3] News in the classification of WHO 2022 testicular tumours
    Colecchia, Maurizio
    Bremmer, Felix
    Pini, Giacomo Maria
    [J]. PATHOLOGICA, 2023, 115 (01) : 3 - 7
  • [4] The Leydig cell tumour Scaled Score (LeSS): a method to distinguish benign from malignant cases, with additional correlation withMDM2andCDK4amplification
    Colecchia, Maurizio
    Bertolotti, Alessia
    Paolini, Biagio
    Giunchi, Francesca
    Necchi, Andrea
    Paganoni, Anna M.
    Ricci, Costantino
    Fiorentino, Michelangelo
    Dagrada, Gian P.
    [J]. HISTOPATHOLOGY, 2021, 78 (02) : 290 - 299
  • [5] The World Health Organization 2016 classification of testicular non-germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel
    Idrees, Muhammad T.
    Ulbright, Thomas M.
    Oliva, Esther
    Young, Robert H.
    Montironi, Rodolfo
    Egevad, Lars
    Berney, Daniel
    Srigley, John R.
    Epstein, Jonathan I.
    Tickoo, Satish K.
    [J]. HISTOPATHOLOGY, 2017, 70 (04) : 513 - 521
  • [6] Genomic Features of Metastatic Testicular Sex Cord Stromal Tumors
    Necchi, Andrea
    Bratslavsky, Gennady
    Shapiro, Oleg
    Elvin, Julia A.
    Vergilio, Jo-Anne
    Killian, Jonathan K.
    Ngo, Nhu
    Ramkissoon, Shakti
    Severson, Eric
    Hemmerich, Amanda C.
    Ali, Siraj M.
    Chung, Jon H.
    Reddy, Prasanth
    Miller, Vincent A.
    Schrock, Alexa B.
    Gay, Laurie M.
    Ross, Jeffrey S.
    Jacob, Joseph M.
    [J]. EUROPEAN UROLOGY FOCUS, 2019, 5 (05): : 748 - 755
  • [7] Raza Mohammed, 2014, J Surg Tech Case Rep, V6, P15, DOI 10.4103/2006-8808.135140
  • [8] Comparative molecular analysis of testicular Leydig cell tumors demonstrates distinct subsets of neoplasms with aggressive histopathologic features
    Rizzo, Natalie M.
    Sholl, Lynette M.
    Idrees, Muhammad T.
    Cheville, John C.
    Gupta, Sounak
    Cornejo, Kristine M.
    Miyamoto, Hiroshi
    Hirsch, Michelle S.
    Collins, Katrina
    Acosta, Andres M.
    [J]. MODERN PATHOLOGY, 2021, 34 (10) : 1935 - 1946
  • [9] Pathologic Risk Factors in Pediatric and Adolescent Patients With Clinical Stage I Testicular Stromal Tumors
    Rove, Kyle O.
    Maroni, Paul D.
    Cost, Carrye R.
    Fairclough, Diane L.
    Giannarini, Gianluca
    Harris, Anne K.
    Schultz, Kris A. P.
    Cost, Nicholas G.
    [J]. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2015, 37 (08) : E441 - E446
  • [10] Leydig cell tumors of the testis with unusual features - Adipose differentiation, calcification with ossification, and spindle-shaped tumor cells
    Ulbright, TM
    Srigley, JR
    Hatzianastassiou, DK
    Young, RH
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2002, 26 (11) : 1424 - 1433
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