Glycogen synthase kinase-3: A potential target for diabetes

被引：26

作者：

Teli, Divya M. ^{[1
]}

Gajjar, Anuradha K. ^{[1
]}

机构：

[1] LM Coll Pharm, Dept Pharmaceut Chem & Qual Assurance, Ahmadabad 380009, Gujarat, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2023年 / 92卷

关键词：

Glycogen synthase kinase-3; Glycogen metabolism; Diabetes; Inhibitors; ALZHEIMERS-DISEASE; GSK-3; INHIBITORS; PROTEIN-KINASE; SUBSTRATE-SPECIFICITY; MOLECULAR-MECHANISM; TAU PHOSPHORYLATION; PEPTIDE INHIBITORS; STRUCTURAL BASIS; PHASE-II; INSULIN;

D O I：

10.1016/j.bmc.2023.117406

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Elevated circulating glucose level due to & beta;-cell dysfunction has been a key marker of Type-II diabetes. Glycogen synthase kinase-3 (GSK-3) has been recognized as an enzyme involved in the control of glycogen metabolism. Consequently, inhibitors of GSK-3 have been explored for anti-diabetic effects in vitro and in animal models. Further, the mechanisms governing the regulation of this enzyme have been elucidated by means of a combination of structural and cellular biological investigations. This review article examines the structural analysis of GSK-3 as well as molecular modeling reports from numerous researchers in the context of the design and development of GSK-3 inhibitors. This article centers on the signaling pathway of GSK-3 relevant to its potential as a target for diabetes and discusses advancements till date on different molecular modification approaches used by researchers in the development of novel GSK-3 inhibitors as potential therapeutics for the treatment of Type II diabetes.

引用

页数：19

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