One carbon metabolic enzyme MTHFD2 is essential for breast cancer metastasis to lung

被引：0
|
作者：
Wang, Yuming [1 ]
Nishimura, Tatsunori [1 ]
Li, Mengjiao [1 ]
Yao, Ryoji [2 ]
Gotoh, Noriko [1 ]
机构：
[1] Kanazawa Univ, Canc Res Ctr, Dept Canc Cell Bil, Kanazawa, Ishikawa, Japan
[2] Japanese Fdn Canc Res, Dept Cell Biol, Tokyo, Japan
来源：
CANCER SCIENCE | 2023年 / 114卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
P-1132
引用
收藏
页码：375 / 375
页数：1
相关论文
共 50 条
  • [41] The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation
    Man Shang
    Huijie Yang
    Ran Yang
    Tao Chen
    Yuan Fu
    Yeyi Li
    Xianlong Fang
    Kangjian Zhang
    Jianju Zhang
    Hui Li
    Xueping Cao
    Jinfa Gu
    Jianwen Xiao
    Qi Zhang
    Xinyuan Liu
    Qiujing Yu
    Ting Wang
    Nature Communications, 12
  • [42] Suppression of MTHFD2 in MCF-7 Breast Cancer Cells Increases Glycolysis, Dependency on Exogenous Glycine, and Sensitivity to Folate Depletion
    Koufaris, Costas
    Gallage, Suchira
    Yang, Tianlai
    Lau, Chung-Ho
    Valbuena, Gabriel N.
    Keun, Hector C.
    JOURNAL OF PROTEOME RESEARCH, 2016, 15 (08) : 2618 - 2625
  • [43] Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor
    Gustafsson, Robert
    Jemth, Ann-Sofie
    Gustafsson, Nina M. S.
    Farnegardh, Katarina
    Loseva, Olga
    Wiita, Elisee
    Bonagas, Nadilly
    Dahllund, Leif
    Llona-Minguez, Sabin
    Haggblad, Maria
    Henriksson, Martin
    Andersson, Yasmin
    Homan, Evert
    Helleday, Thomas
    Stenmark, Pal
    CANCER RESEARCH, 2017, 77 (04) : 937 - 948
  • [44] High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion
    Lehtinen, Laura
    Ketola, Kirsi
    Makela, Rami
    Mpindi, John-Patrick
    Viitala, Miro
    Kallioniemi, Olli
    Iljin, Kristiina
    ONCOTARGET, 2013, 4 (01) : 48 - 63
  • [45] "Serine and One-Carbon Metabolism in Breast Cancer Metastasis"-Letter
    Kinslow, Connor J.
    Sun, Ramon C.
    Chaudhary, Kunal R.
    Cheng, Simon K.
    MOLECULAR CANCER RESEARCH, 2020, 18 (11) : 1755 - 1755
  • [46] The ratio of key metabolic transcripts is a predictive biomarker of breast cancer metastasis to the lung
    Mathur, Deepti
    Liao, Chen
    Lin, Wendy
    La Ferlita, Alessandro
    Alaimo, Salvatore
    Ferro, Alfredo
    Zhong, Yi
    Iacobuzio-Donahue, Christine
    Xavier, Joao
    CANCER RESEARCH, 2023, 83 (07)
  • [47] NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis
    Park, Mi Kyung
    Zhang, Li
    Min, Kyung-Won
    Cho, Jung-Hyun
    Yeh, Chih-Chen
    Moon, Hyesu
    Hormaechea-Agulla, Daniel
    Mun, Hyejin
    Ko, Seungbeom
    Lee, Ji Won
    Jathar, Sonali
    Smith, Aubrey S.
    Yao, Yixin
    Giang, Nguyen Thu
    Ha Vu, Hong
    Yan, Victoria C.
    Bridges, Mary C.
    Kourtidis, Antonis
    Muller, Florian
    Chang, Jeong Ho
    Song, Su Jung
    Nakagawa, Shinichi
    Hirose, Tetsuro
    Yoon, Je-Hyun
    Song, Min Sup
    CELL METABOLISM, 2021, 33 (12) : 2380 - +
  • [48] The Ratio of Key Metabolic Transcripts Is a Predictive Biomarker of Breast Cancer Metastasis to the Lung
    Mathur, Deepti
    Liao, Chen
    Lin, Wendy
    La Ferlita, Alessandro
    Alaimo, Salvatore
    Taylor, Samuel
    Zhong, Yi
    Iacobuzio-Donahue, Christine
    Ferro, Alfredo
    Xavier, Joao B.
    CANCER RESEARCH, 2023, 83 (20) : 3478 - 3491
  • [49] The Metabolic Mechanisms of Breast Cancer Metastasis
    Wang, Lingling
    Zhang, Shizhen
    Wang, Xiaochen
    FRONTIERS IN ONCOLOGY, 2021, 10
  • [50] MicroRNA-33a-5p suppresses colorectal cancer cell growth by inhibiting MTHFD2
    Yan, Yan
    Zhang, Ding
    Lei, Ting
    Zhao, Chang'an
    Han, Jia
    Cui, Jiarui
    Wang, Yili
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2019, 46 (10) : 928 - 936
12345