One carbon metabolic enzyme MTHFD2 is essential for breast cancer metastasis to lung

被引：0
|
作者：
Wang, Yuming [1 ]
Nishimura, Tatsunori [1 ]
Li, Mengjiao [1 ]
Yao, Ryoji [2 ]
Gotoh, Noriko [1 ]
机构：
[1] Kanazawa Univ, Canc Res Ctr, Dept Canc Cell Bil, Kanazawa, Ishikawa, Japan
[2] Japanese Fdn Canc Res, Dept Cell Biol, Tokyo, Japan
来源：
CANCER SCIENCE | 2023年 / 114卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
P-1132
引用
收藏
页码：375 / 375
页数：1
相关论文
共 50 条
  • [31] A Review of Small-Molecule Inhibitors of One-Carbon Enzymes: SHMT2 and MTHFD2 in the Spotlight
    Cuthbertson, Christine R.
    Arabzada, Zahra
    Bankhead, Armand, III
    Kyani, Armita
    Neamati, Nouri
    ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 2021, 4 (02) : 624 - 646
  • [32] The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation
    Sheppard, Nina Gustafsson
    Jarl, Lisa
    Mahadessian, Diana
    Strittmatter, Laura
    Schmidt, Angelika
    Madhusudan, Nikhil
    Tegner, Jesper
    Lundberg, Emma K.
    Asplund, Anna
    Jain, Mohit
    Nilsson, Roland
    SCIENTIFIC REPORTS, 2015, 5
  • [33] The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation
    Nina Gustafsson Sheppard
    Lisa Jarl
    Diana Mahadessian
    Laura Strittmatter
    Angelika Schmidt
    Nikhil Madhusudan
    Jesper Tegnér
    Emma K. Lundberg
    Anna Asplund
    Mohit Jain
    Roland Nilsson
    Scientific Reports, 5
  • [34] A mitochondrial one-carbon metabolism promotes breast cancer tumorigenesis and lung metastasis
    Hongu, Tsunaki
    Wang, Yuming
    Nishimura, Tatsunori
    Daikoku, Takiko
    Yao, Ryoji
    Kojo, Satoshi
    Watarai, Hiroshi
    Soga, Tomoyoshi
    Gotoh, Noriko
    CANCER SCIENCE, 2025, 116 : 56 - 56
  • [35] Cancer stem-like properties and drug resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2
    Gotoh, Noriko
    Nishimura, Tatsunori
    Nakata, Asuka
    Horike, Shin-ichi
    Kohno, Susumu
    Takahashi, Chiaki
    Soga, Tomoyoshi
    Tojo, Arinobu
    CANCER RESEARCH, 2018, 78 (13)
  • [36] Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2
    Tatsunori Nishimura
    Asuka Nakata
    Xiaoxi Chen
    Kurumi Nishi
    Makiko Meguro-Horike
    Soichiro Sasaki
    Kenji Kita
    Shin-ichi Horike
    Kaori Saitoh
    Keiko Kato
    Kaori Igarashi
    Takahiko Murayama
    Susumu Kohno
    Chiaki Takahashi
    Naofumi Mukaida
    Seiji Yano
    Tomoyoshi Soga
    Arinobu Tojo
    Noriko Gotoh
    Oncogene, 2019, 38 : 2464 - 2481
  • [37] Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2
    Nishimura, Tatsunori
    Nakata, Asuka
    Chen, Xiaoxi
    Nishi, Kurumi
    Meguro-Horike, Makiko
    Sasaki, Soichiro
    Kita, Kenji
    Horike, Shin-ichi
    Saitoh, Kaori
    Kato, Keiko
    Igarashi, Kaori
    Murayama, Takahiko
    Kohno, Susumu
    Takahashi, Chiaki
    Mukaida, Naofumi
    Yano, Seiji
    Soga, Tomoyoshi
    Tojo, Arinobu
    Gotoh, Noriko
    ONCOGENE, 2019, 38 (14) : 2464 - 2481
  • [38] Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response
    Ramos, Louise
    Henriksson, Martin
    Helleday, Thomas
    Green, Alanna C.
    CANCER RESEARCH, 2024, 84 (01) : 9 - 16
  • [39] Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications
    Ju, Huai-Qiang
    Lu, Yun-Xin
    Chen, Dong-Liang
    Zuo, Zhi-Xiang
    Liu, Ze-Xian
    Wu, Qi-Nian
    Mo, Hai-Yu
    Wang, Zi-Xian
    Wang, De-Shen
    Pu, Heng-Ying
    Zeng, Zhao-Lei
    Li, Bo
    Xie, Dan
    Huang, Peng
    Hung, Mien-Chie
    Chiao, Paul J.
    Xu, Rui-Hua
    JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2019, 111 (06): : 584 - 596
  • [40] The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation
    Shang, Man
    Yang, Huijie
    Yang, Ran
    Chen, Tao
    Fu, Yuan
    Li, Yeyi
    Fang, Xianlong
    Zhang, Kangjian
    Zhang, Jianju
    Li, Hui
    Cao, Xueping
    Gu, Jinfa
    Xiao, Jianwen
    Zhang, Qi
    Liu, Xinyuan
    Yu, Qiujing
    Wang, Ting
    NATURE COMMUNICATIONS, 2021, 12 (01)
12345