ROS induced lipid peroxidation and their role in ferroptosis

被引：148

作者：

Endale, Hiwot Tezera ^{[1
]}

Tesfaye, Winta ^{[2
]}

Mengstie, Tiget Ayelgn ^{[2
]}

机构：

[1] Univ Gondar, Coll Med & Hlth Sci, Sch Med, Dept Biochem, Gondar, Ethiopia

[2] Univ Gondar, Coll Med & Hlth Sci, Sch Med, Dept Human Physiol, Gondar, Ethiopia

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷

关键词：

ROS; lipid peroxidation; autophagy; ferroptosis; apoptosis; REACTIVE OXYGEN; IRON; AUTOPHAGY; CANCER; ANTIOXIDANTS; MEMBRANE; DEATH;

D O I：

10.3389/fcell.2023.1226044

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reactive oxygen species (ROS) play a crucial part in the process of cell death, including apoptosis, autophagy, and ferroptosis. ROS involves in the oxidation of lipids and generate 4-hydroxynonenal and other compounds associated with it. Ferroptosis may be facilitated by lipid peroxidation of phospholipid bilayers. In order to offer novel ideas and directions for the investigation of disorders connected to these processes, we evaluate the function of ROS in lipid peroxidation which ultimately leads to ferroptosis as well as proposed crosstalk mechanisms between ferroptosis and other types programmed cell death.

引用

页数：7

共 78 条

[21] Identification of ACSL4 as a biomarker and contributor of ferroptosis in clear cell renal cell carcinoma [J].

Guo, Na .

TRANSLATIONAL CANCER RESEARCH, 2022, 11 (08) :2688-2699

[22] SnapShot: Ferroptosis [J].

Hadian, Kamyar ;

Stockwell, Brent R. .

CELL, 2020, 181 (05) :1188-U472

[23]

Halliwell B., 2015, Free radicals in biology and medicine

[24] Oxidized phospholipids-Their properties and interactions with proteins [J].

Hermetter, Albin ;

Kinnunen, Paavo ;

Spickett, Corinne .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2012, 1818 (10) :2373-2373

[25] Autophagy promotes ferroptosis by degradation of ferritin [J].

Hou, Wen ;

Xie, Yangchun ;

Song, Xinxin ;

Sun, Xiaofang ;

Lotze, Michael T. ;

Zeh, Herbert J. ;

Kang, Rui ;

Tang, Daolin .

AUTOPHAGY, 2016, 12 (08) :1425-1428

[26] Mitochondria and ferroptosis [J].

Javadov, Sabzali .

CURRENT OPINION IN PHYSIOLOGY, 2022, 25

[27] p53: A double-edged sword in tumor ferroptosis [J].

Ji, Haixia ;

Wang, Wenzhe ;

Li, Xia ;

Han, Xiaoying ;

Zhang, Xinyu ;

Wang, Juan ;

Liu, Changxiao ;

Huang, Luqi ;

Gao, Wenyuan .

PHARMACOLOGICAL RESEARCH, 2022, 177

[28] Ferroptosis as a p53-mediated activity during tumour suppression [J].

Jiang, Le ;

Kon, Ning ;

Li, Tongyuan ;

Wang, Shang-Jui ;

Su, Tao ;

Hibshoosh, Hanina ;

Baer, Richard ;

Gu, Wei .

NATURE, 2015, 520 (7545) :57-+

[29] Ferroptosis: mechanisms, biology and role in disease [J].

Jiang, Xuejun ;

Stockwell, Brent R. ;

Conrad, Marcus .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2021, 22 (04) :266-282

[30] The tumor suppressor protein p53 and the ferroptosis network [J].

Kang, Rui ;

Kroemer, Guido ;

Tang, Daolin .

FREE RADICAL BIOLOGY AND MEDICINE, 2019, 133 :162-168

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