ROS induced lipid peroxidation and their role in ferroptosis

被引:157
作者
Endale, Hiwot Tezera [1 ]
Tesfaye, Winta [2 ]
Mengstie, Tiget Ayelgn [2 ]
机构
[1] Univ Gondar, Coll Med & Hlth Sci, Sch Med, Dept Biochem, Gondar, Ethiopia
[2] Univ Gondar, Coll Med & Hlth Sci, Sch Med, Dept Human Physiol, Gondar, Ethiopia
来源
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷
关键词
ROS; lipid peroxidation; autophagy; ferroptosis; apoptosis; REACTIVE OXYGEN; IRON; AUTOPHAGY; CANCER; ANTIOXIDANTS; MEMBRANE; DEATH;
D O I
10.3389/fcell.2023.1226044
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Reactive oxygen species (ROS) play a crucial part in the process of cell death, including apoptosis, autophagy, and ferroptosis. ROS involves in the oxidation of lipids and generate 4-hydroxynonenal and other compounds associated with it. Ferroptosis may be facilitated by lipid peroxidation of phospholipid bilayers. In order to offer novel ideas and directions for the investigation of disorders connected to these processes, we evaluate the function of ROS in lipid peroxidation which ultimately leads to ferroptosis as well as proposed crosstalk mechanisms between ferroptosis and other types programmed cell death.
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页数:7
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