Bioinformatics-based analysis of the roles of sex hormone receptors in endometriosis development

被引：3

作者：

Zhao, Xiaoling ^{[1
]}

Kong, Weimin ^{[1
]}

Zhou, Chunxiao ^{[2
,3
]}

Deng, Boer ^{[1
,2
,3
]}

Zhang, He ^{[1
]}

Guo, Huimin ^{[1
]}

Chen, Shuning ^{[1
]}

Pan, Zhendong ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing Maternal & Child Hlth Care Hosp, Dept Gynecol Oncol, Beijing, Peoples R China

[2] Univ North Carolina Chapel Hill, Div Gynecol Oncol, Chapel Hill, NC USA

[3] Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA

来源：

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2023年 / 20卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Endometriosis; Hormone receptor; Bioinformatics analysis; ANDROGEN RECEPTOR; PROGESTERONE; PROTEIN; CANCER; GENE; ACTIVATION; CYTOSINE; NETWORK; ADENINE;

D O I：

10.7150/ijms.79516

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endometriosis is a hormone-dependent disease in women of reproductive age and seriously affects women's health. To analyze the involvement of sex hormone receptors in endometriosis development, we performed bioinformatics analysis using four datasets derived from the Gene Expression Omnibus (GEO) database, which may help us understand the mechanisms by which the sex hormones act in vivo in endometriosis patients. The enrichment analysis and protein-protein interaction (PPI) analysis of the differentially expressed genes (DEGs) revealed that there are different key genes and pathways involved in eutopic endometrium aberrations of endometriosis patients and endometriotic lesions, and sex hormone receptors, including androgen receptor (AR), progesterone receptor (PGR) and estrogen receptor 1 (ESR1), may play important roles in endometriosis development. Androgen receptor (AR), as the hub gene of endometrial aberrations in endometriotic patients, showed positive expression in the main cell types for endometriosis development, and its decreased expression in the endometrium of endometriotic patients was also confirmed by immunohistochemistry (IHC). The nomogram model established based on it displayed good predictive value.

引用

页码：415 / 428

页数：14