Potential role of statins in treatment of acute sarcopenia

被引：4

作者：

De Spiegeleer, Anton ^{[1
,2
,3
]}

Kahya, Hasan ^{[1
]}

Crombez, Liesbeth ^{[1
,2
]}

Descamps, Amelie ^{[1
,4
]}

Rossler, Roland ^{[5
]}

Kressig, Reto W. ^{[5
]}

Lapauw, Bruno ^{[6
]}

Wynendaele, Evelien ^{[1
,4
]}

Elewaut, Dirk ^{[1
,3
,7
]}

De Spiegeleer, Bart ^{[1
,4
]}

Van Den Noortgate, Nele ^{[1
,2
]}

机构：

[1] Univ Ghent, Translat Res Immunosenescence Gerontol & Geriatr T, Ghent, Belgium

[2] Ghent Univ Hosp, Fac Med & Hlth Sci, Geriatr Dept, Ghent, Belgium

[3] Univ Ghent, Ctr Inflammat Res VIB, Unit Mol Immunol & Inflammat, Ghen, Belgium

[4] Univ Ghent, Fac Pharmaceut Sci, Drug Qual & Registrat DruQuaR Grp, Ghent, Belgium

[5] Univ Basel, Univ Dept Geriatr Med FELIX PLATTER, Basel, Switzerland

[6] Ghent Univ Hosp, Fac Med & Hlth Sci, Endocrinol Dept, Ghent, Belgium

[7] Ghent Univ Hosp, Fac Med & Hlth Sci, Rheumatol Dept, Ghent, Belgium

来源：

MEDICAL HYPOTHESES | 2023年 / 177卷

关键词：

Sarcopenia; Statins; Drug repurposing; INPATIENT REHABILITATION; INSULIN-RESISTANCE; OLDER-ADULTS; ASSOCIATION; HOSPITALIZATION; MUSCLE; RISK; MECHANISMS; INFLAMMATION; DISABILITY;

D O I：

10.1016/j.mehy.2023.111111

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Accelerated muscle aging, known as sarcopenia, is a geriatric condition that poses significant health risks both for individuals and society. Hospitalization can trigger a sudden deterioration of sarcopenia, making it imperative to find effective interventions targeting this acute sarcopenia. Drug repurposing, which involves utilizing 'old' medications for new indications, could be a cost-effective and faster solution as the safety of these drugs has already been established in the old population. The authors propose that short-term use of low-dose statins may be a promising option for preventing and treating acute sarcopenia. This hypothesis is based on the mechanisms of action of statins, which demonstrate hormesis-like effects with no direct muscle-toxic effects at low doses, as well as muscle-beneficial indirect effects through other body systems such as the immune-endothelial system and the gut microbiota at low doses. Additionally, supportive observational studies suggest beneficial muscle effects in inflammatory subgroups of older people, with a safe track record of statins in older people at short-term low doses. Therefore, it is hypothesized that statins may be of potential benefit in combating acute sarcopenia.

引用

页数：6

共 86 条

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