Safety and immunogenicity of a third dose of COVID-19 protein subunit vaccine (CovovaxTM) after homologous and heterologous two-dose regimens

被引：9

作者：

Kanokudom, Sitthichai ^{[1
,2
]}

Chansaenroj, Jira ^{[1
]}

Suntronwong, Nungruthai ^{[1
]}

Assawakosri, Suvichada ^{[1
,2
]}

Yorsaeng, Ritthideach ^{[1
]}

Nilyanimit, Pornjarim ^{[1
]}

Aeemjinda, Ratchadawan ^{[1
]}

Khanarat, Nongkanok ^{[1
]}

Vichaiwattana, Preeyaporn ^{[1
]}

Klinfueng, Sirapa ^{[1
]}

Thongmee, Thanunrat ^{[1
]}

Katanyutanon, Apirat ^{[3
]}

Thanasopon, Wichai ^{[3
]}

Arayapong, Jirawan ^{[4
]}

Withaksabut, Withak ^{[3
]}

Srimuan, Donchida ^{[1
]}

Thatsanatorn, Thaksaporn ^{[1
]}

Sudhinaraset, Natthinee ^{[1
]}

Wanlapakorn, Nasamon ^{[1
]}

Honsawek, Sittisak ^{[2
]}

Poovorawan, Yong ^{[1
,5
]}

机构：

[1] Chulalongkorn Univ, Fac Med, Ctr Excellence Clin Virol, Bangkok, Thailand

[2] Chulalongkorn Univ, King Chulalongkorn Mem Hosp, Fac Med, Ctr Excellence Osteoarthritis & Musculoskeleton, Bangkok, Thailand

[3] Chonburi Prov Publ Hlth Off, Chon Buri, Thailand

[4] Chonburi Hosp, Chon Buri, Thailand

[5] Royal Soc Thailand, Sanam Sueapa, Fellow Royal Soc Thailand FRST, Bangkok, Thailand

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2023年 / 126卷

关键词：

SARS-CoV-2; Omicron; Side effect; CovovaxTM; Novavax; Booster dose;

D O I：

10.1016/j.ijid.2022.11.022

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: To report the safety and immunogenicity profile of a protein subunit vaccine (CovovaxTM) given as a third (booster) dose to individuals primed with different primary vaccine regimens. Methods: A third dose was administered to individuals with an interval range of 3-10 months after the second dose. The four groups were classified according to their primary vaccine regimens, including two dose BBIBP-CorV, AZD1222, BNT162b2, and CoronaVac/AZD1222. Immunogenicity analysis was performed to determine binding antibodies, neutralizing activity, and the T-cell responses.Results: Overall, 210 individuals were enrolled and boosted with the CovovaxTM vaccine. The reactogenicity was mild to moderate. Most participants elicited a high level of binding and neutralizing antibody against Wild-type and Omicron variants after the booster dose. In participants who were antinucleocapsid immunoglobulin G-negative from all groups, a booster dose could elicit neutralizing activity to Wild type and Omicron variants by more than 95% and 70% inhibition at 28 days, respectively. The CovovaxTM vaccine could elicit a cell-mediated immune response.Conclusion: The protein subunit vaccine (CovovaxTM) can be proposed as a booster dose after two different priming dose regimens. It has strong immunogenicity and good safety profiles.& COPY; 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )

引用

页码：64 / 72

页数：9

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