Recent Advances in the Synthesis and Application of C-2-Formyl Glycals

C-2-Formyl glycals have sustained interest in carbohydrate chemistry as they afford valuable chiral building blocks for many biological-, pharmaceutical-, and industrial-based important molecules. Basically, C-2-formyl glycals are a class of carbohydrates incorporating an.,.-unsaturated aldehyde. Therefore in many organic reactions, the C2-formyl glycals can serve as an alpha,beta-unsaturated aldehyde core. In this review, we have compiled a literature survey covering the period 20132022, on the synthesis of C-2-formyl glycals and further discuss their importance for the synthesis of many medicinal, supramolecular, biological, organic, and material chemistry based molecules. 1 Introduction 2 Synthesis of C-2-Formyl Glycals 2.1 Vilsmeier-Haack Formylation 2.2 By Consecutive Cyclization 2.3 XtalFluor-E Based Synthesis 3 Applications of C-2-Formyl Glycals 3.1 C-2-Formyl Glycals as a Synthons 3.2 Anticancer 3.3 Anti-inflammatory 3.4 Antimicrobial 3.5 Glycosidase Inhibitors 3.6 Miscellaneous 4 Conclusion and Future Aspects