Association of clinical factors to functional outcomes in patients with stroke with large- vessel occlusion after endovascular thrombectomy

被引:9
作者
Lin, Meng -Ting [1 ]
Wu, Hao-Wei [2 ]
Chen, Hsing-Yu [2 ]
Tsai, Hsiao-Ting [2 ]
Wu, Chueh-Hung [1 ]
机构
[1] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Phys Med & Rehabil, Taipei 100, Taiwan
[2] Natl Taiwan Univ Hosp, Dept Phys Med & Rehabil, Hsin Chu Branch, Hsinchu, Taiwan
关键词
Prognostic factors; Ischemic stroke; Endovascular thrombectomy; ACUTE ISCHEMIC-STROKE; MECHANICAL THROMBECTOMY; PROGNOSTIC-FACTORS; PREDICTION; SCORE; REHABILITATION;
D O I
10.1016/j.jfma.2022.11.016
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/Purpose: Multiple clinical factors have been reported to be associated with functional outcomes in patients with stroke. However, little is known about prognostic predictors of functional independence in patients with stroke undergoing endovascular throm-bectomy (EVT). Our study aimed to investigate the correlation between multiple prognostic variables (including EVT and rehabilitation-related parameters) and functional outcomes in pa-tients post-EVT. Methods: This retrospective cohort study recruited patients hospitalized between December 2018 and March 2022. Patients with stroke with large-vessel occlusion who underwent EVT were eligible for inclusion in the study. Prognostic factors, including premorbid characteristics, laboratory data, EVT-and rehabilitation-related parameters, functional activity level, balance ability, swallowing, and sphincter function, were collected. Logistic regression and general-ized linear models were used to analyze their correlations with functional outcomes. Results: A total of 148 patients were included. In the univariate logistic regression analysis, younger age, premorbid functional independence, higher hemoglobin (Hb) level, lower Na-tional Institute of Health Stroke Scale (NIHSS) score, absence of hemorrhagic transformation in 14 days, no nasogastric (NG) tube placement, earlier rehabilitation, frequent daily rehabil-itation sessions, more out-of-bed rehabilitation, better ability of sitting up, better initial sitting balance, higher Barthel index (BI), absence of immobility, and neurological complica-tions were associated with favorable outcomes at 3 months. In the stepwise regression model, the predictors of favorable function at 3 months included age, ability to sit up, and frequency of daily rehabilitation sessions; favorable outcomes at 6 months were associated with age, ability to sit up, and swallowing function. Conclusion: In patients with stroke post-EVT, better functional outcomes were associated with prognostic variables, including younger age, better ability to sit up, normal swallowing func-tion, and frequent daily rehabilitation sessions.Copyright 2022, Formosan Medical Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码:344 / 350
页数:7
相关论文
共 39 条
[1]   Outcomes of endovascular thrombectomy in the elderly: a 'real-world' multicenter study [J].
Alawieh, Ali ;
Starke, Robert M. ;
Chatterjee, Arindam Rano ;
Turk, Aquilla ;
De Leacy, Reade ;
Rai, Ansaar T. ;
Fargen, Kyle ;
Kan, Peter ;
Singh, Jasmeet ;
Vilella, Lukas ;
Nascimento, Fabio A. ;
Dumont, Travis M. ;
McCarthy, David ;
Spiotta, Alejandro M. .
JOURNAL OF NEUROINTERVENTIONAL SURGERY, 2019, 11 (06) :545-553
[2]   Impact of Age and Baseline NIHSS Scores on Clinical Outcomes in the Mechanical Thrombectomy Using Solitaire FR in Acute Ischemic Stroke Study [J].
Almekhlafi, M. A. ;
Davalos, A. ;
Bonafe, A. ;
Chapot, R. ;
Gralla, J. ;
Pereira, V. M. ;
Goyal, M. .
AMERICAN JOURNAL OF NEURORADIOLOGY, 2014, 35 (07) :1337-1340
[3]   Early rehabilitation after stroke [J].
Bernhardt, Julie ;
Godecke, Erin ;
Johnson, Liam ;
Langhorne, Peter .
CURRENT OPINION IN NEUROLOGY, 2017, 30 (01) :48-54
[4]   The prediction of acute ischemic stroke patients' long-term functional outcomes treated with bridging therapy [J].
Chang, Yu-Jun ;
Liu, Chi-Kuang ;
Wu, Wen-Pei ;
Wang, Shih-Chun ;
Chen, Wei-Liang ;
Lin, Chih-Ming .
BMC NEUROLOGY, 2020, 20 (01)
[5]   Prognostic factors of functional outcome in post-acute stroke in the rehabilitation unit [J].
Chen, Wei-Chieh ;
Hsiao, Ming-Yen ;
Wang, Tyng-Guey .
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2022, 121 (03) :670-678
[6]   Effect of very early mobilisation on functional status in patients with acute stroke: a single-blind, randomized controlled trail [J].
Chippala, Purusotham ;
Sharma, Raghava .
CLINICAL REHABILITATION, 2016, 30 (07) :669-675
[7]   Early Rehabilitation After Stroke: a Narrative Review [J].
Coleman, Elisheva R. ;
Moudgal, Rohitha ;
Lang, Kathryn ;
Hyacinth, Hyacinth I. ;
Awosika, Oluwole O. ;
Kissela, Brett M. ;
Feng, Wuwei .
CURRENT ATHEROSCLEROSIS REPORTS, 2017, 19 (12)
[8]   Prognostic factors related to clinical outcome following thrombectomy in ischemic stroke (RECOST Study). 50 patients prospective study [J].
Costalat, V. ;
Lobotesis, K. ;
Machi, P. ;
Mourand, I. ;
Maldonado, I. ;
Heroum, C. ;
Vendrell, J. F. ;
Milhaud, D. ;
Riquelme, C. ;
Bonafe, A. ;
Arquizan, C. .
EUROPEAN JOURNAL OF RADIOLOGY, 2012, 81 (12) :4075-4082
[9]   The STROBE guidelines [J].
Cuschieri, Sarah .
SAUDI JOURNAL OF ANAESTHESIA, 2019, 13 :31-34
[10]   Effect of malnutrition after acute stroke on clinical outcome [J].
Davalos, A ;
Ricart, W ;
GonzalezHuix, F ;
Soler, S ;
Marrugat, J ;
Molins, A ;
Suner, R ;
Genis, D .
STROKE, 1996, 27 (06) :1028-1032