Systemic immune inflammation index and pan-immune inflammation value as prognostic markers in patients with idiopathic low and moderate risk membranous nephropathy

OBJECTIVE: We aimed to investi-gate the prognostic values of systemic immune inflammation index and pan-immune inflamma-tion value in patients with idiopathic low and moderate risk membranous nephropathy.PATIENTS AND METHODS: All membra-nous nephropathy patients diagnosed in the ne-phrology clinic between January 2015 and Janu-ary 2022 were reviewed retrospectively. Patients with idiopathic membranous nephropathy were included. The patients were divided into two groups; the complete remission group: whose proteinuria decreased below 0.3 g/day and se-rum albumin level above 3.5 g/dL after 6 months of conservative treatment, and the non -remis-sion group: all other patients. Groups were com-pared in terms of systemic immune inflammation index and pan-immune inflammation value.RESULTS: Patients in the non-remission group had significantly higher systemic immune -in-flammation index (SII) and pan-immune -inflam-mation value (PIV) than patients in the complete remission group (p<0.05). An SII of 1,056.2 was found to have 63.6% sensitivity and 100% spec-ificity in predicting non-remission, and a PIV of 447.4 was found to have 100% sensitivity and 70.6% specificity in predicting non-remission.CONCLUSIONS: SII and PIV are reliable mark-ers for predicting non-remission in patients with low and moderate risk idiopathic MN.