Azobenzene derivatives with activity against drug-resistant Candida albicans and Candida auris

被引：4
|
作者：
Raschig, Martina [1 ]
Ramirez-Zavala, Bernardo [2 ]
Wiest, Johannes [1 ]
Saedtler, Marco [1 ]
Gutmann, Marcus [1 ]
Holzgrabe, Ulrike [1 ]
Morschhauser, Joachim [2 ]
Meinel, Lorenz [1 ,3 ]
机构：
[1] Univ Wurzburg, Inst Pharm & Food Chem, DE-97074 Wurzburg, Germany
[2] Univ Wurzburg, Inst Mol Infect Biol IMIB, Wurzburg, Germany
[3] Helmholtz Inst RNA Based Infect Biol HIRI, Wurzburg, Germany
来源：
ARCHIV DER PHARMAZIE | 2023年 / 356卷 / 02期
关键词：
antifungal drug; azobenzenes; Candida albicans; Candida auris; FLUCONAZOLE RESISTANCE; ANTIFUNGAL ACTIVITY; AZO-COMPOUND; EPIDEMIOLOGY; RESVERATROL; INFECTIONS;
D O I：
10.1002/ardp.202200463
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Increasing resistance against antimycotic drugs challenges anti-infective therapies today and contributes to the mortality of infections by drug-resistant Candida species and strains. Therefore, novel antifungal agents are needed. A promising approach in developing new drugs is using naturally occurring molecules as lead structures. In this work, 4,4'-dihydroxyazobenzene, a compound structurally related to antifungal stilbene derivatives and present in Agaricus xanthodermus (yellow stainer), served as a starting point for the synthesis of five azobenzene derivatives. These compounds prevented the growth of both fluconazole-susceptible and fluconazole-resistant Candida albicans and Candida auris strains. Further in vivo studies are required to confirm the potential therapeutic value of these compounds.
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收藏
页数：7
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