Azobenzene derivatives with activity against drug-resistant Candida albicans and Candida auris

被引：4

作者：

Raschig, Martina ^{[1
]}

Ramirez-Zavala, Bernardo ^{[2
]}

Wiest, Johannes ^{[1
]}

Saedtler, Marco ^{[1
]}

Gutmann, Marcus ^{[1
]}

Holzgrabe, Ulrike ^{[1
]}

Morschhauser, Joachim ^{[2
]}

Meinel, Lorenz ^{[1
,3
]}

机构：

[1] Univ Wurzburg, Inst Pharm & Food Chem, DE-97074 Wurzburg, Germany

[2] Univ Wurzburg, Inst Mol Infect Biol IMIB, Wurzburg, Germany

[3] Helmholtz Inst RNA Based Infect Biol HIRI, Wurzburg, Germany

来源：

ARCHIV DER PHARMAZIE | 2023年 / 356卷 / 02期

关键词：

antifungal drug; azobenzenes; Candida albicans; Candida auris; FLUCONAZOLE RESISTANCE; ANTIFUNGAL ACTIVITY; AZO-COMPOUND; EPIDEMIOLOGY; RESVERATROL; INFECTIONS;

D O I：

10.1002/ardp.202200463

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Increasing resistance against antimycotic drugs challenges anti-infective therapies today and contributes to the mortality of infections by drug-resistant Candida species and strains. Therefore, novel antifungal agents are needed. A promising approach in developing new drugs is using naturally occurring molecules as lead structures. In this work, 4,4'-dihydroxyazobenzene, a compound structurally related to antifungal stilbene derivatives and present in Agaricus xanthodermus (yellow stainer), served as a starting point for the synthesis of five azobenzene derivatives. These compounds prevented the growth of both fluconazole-susceptible and fluconazole-resistant Candida albicans and Candida auris strains. Further in vivo studies are required to confirm the potential therapeutic value of these compounds.

引用

页数：7

共 29 条

[1] Epidemiology of invasive candidiasis [J].

Arendrup, Maiken C. .

CURRENT OPINION IN CRITICAL CARE, 2010, 16 (05) :445-452

[2] Synthesis and characterization of azobenzene derivatives and azobenzene-imidazolium conjugates with selective antimicrobial potential [J].

Babamale, Halimah Funmilayo ;

Sangeetha, Thiagarajan ;

Tan, Joo Shun ;

Yam, WanSinn .

JOURNAL OF MOLECULAR STRUCTURE, 2021, 1232

[3] Surface and biocidal activity of some synthesized metallo azobenzene isothiouronium salts [J].

Badawi, A. M. ;

Azzam, E. M. S. ;

Morsy, S. M. I. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (24) :8661-8665

[4] Declining Incidence of Candidemia and the Shifting Epidemiology of Candida Resistance in Two US Metropolitan Areas, 2008-2013: Results from Population-Based Surveillance [J].

Cleveland, Angela Ahlquist ;

Harrison, Lee H. ;

Farley, Monica M. ;

Hollick, Rosemary ;

Stein, Betsy ;

Chiller, Tom M. ;

Lockhart, Shawn R. ;

Park, Benjamin J. .

PLOS ONE, 2015, 10 (03)

[5] Structure Modification of an Active Azo-Compound as a Route to New Antimicrobial Compounds [J].

Concilio, Simona ;

Sessa, Lucia ;

Petrone, Anna Maria ;

Porta, Amalia ;

Diana, Rosita ;

Iannelli, Pio ;

Piotto, Stefano .

MOLECULES, 2017, 22 (06)

[6] Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris [J].

Cortegiani, Andrea ;

Misseri, Giovanni ;

Fasciana, Teresa ;

Giammanco, Anna ;

Giarratano, Antonino ;

Chowdhary, Anuradha .

JOURNAL OF INTENSIVE CARE, 2018, 6

[7] Azobenzene as Antimicrobial Molecules [J].

Di Martino, Miriam ;

Sessa, Lucia ;

Di Matteo, Martina ;

Panunzi, Barbara ;

Piotto, Stefano ;

Concilio, Simona .

MOLECULES, 2022, 27 (17)

[8] Epidemiology of Candida species infections in critically ill non-immunosuppressed patients [J].

Eggimann, P ;

Garbino, J ;

Pittet, D .

LANCET INFECTIOUS DISEASES, 2003, 3 (11) :685-702

[9]

GILL M, 1984, Z NATURFORSCH C, V39, P1027

[10] ISOLATION OF THE CANDIDA-ALBICANS GENE FOR OROTIDINE-5'-PHOSPHATE DECARBOXYLASE BY COMPLEMENTATION OF S-CEREVISIAE URA3 AND ESCHERICHIA-COLI PYRF MUTATIONS [J].

GILLUM, AM ;

TSAY, EYH ;

KIRSCH, DR .

MOLECULAR & GENERAL GENETICS, 1984, 198 (01) :179-182

← 1 2 3 →