High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury

被引:2
|
作者
Cheff, Veronique [1 ,2 ]
Trentin-Sonoda, Mayra [1 ,2 ]
Blais, Amelie [1 ,2 ]
Thibodeau, Jean-Francois [1 ,2 ,3 ]
Holterman, Chet E. [1 ,2 ]
Gutsol, Alex [1 ,2 ]
Kennedy, Christopher R. J. [1 ,2 ]
Hebert, Richard L. [2 ]
机构
[1] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada
[2] Ottawa Hosp Res Inst, Kidney Res Ctr, Dept Med, Div Nephrol, Ottawa, ON, Canada
[3] Liminal Biosci Inc, Laval, PQ, Canada
来源
PLOS ONE | 2023年 / 18卷 / 02期
关键词
MOUSE MODEL; METABOLIC SYNDROME; BLOOD-PRESSURE; RENAL-DISEASE; HYPERGLYCEMIA; NEPHROPATHY; PROTEINURIA;
D O I
10.1371/journal.pone.0281123
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Chronic kidney disease (CKD) is a worldwide health burden with increases risk of end-stage renal function if left untreated. CKD induced in the context of metabolic syndrome (MS) increases risks of hypertension, hyperglycemia, excess body fat and dyslipidemia. To test if combining a high-fat diet (HFD) regimen onto the hypertensive/ diabetic phenotype would mimic features of MS induced-CKD in mice, hyperglycemia was induced in genetically hypertensive mice (Lin), followed by HFD regimen. For that, 8-week-old male were subjected to streptozotocin (STZ) intraperitoneal (i.p.) injections (50 mg/kg, 5 days consecutive). LinSTZ were fed a 60% kCal HFD for 8 weeks. Lin mice treated with STZ developed polydipsia, became hypertensive and hyperglycemic. HFD induced weight gain, protected against glomerular hypertrophy, scarring, and albuminuria at endpoint compared to regular diet fed LinSTZ. On the other hand, HFD induced steatosis, liver fibrosis, inflammation, and increase in AST/ALT ratio, characteristics of non-alcoholic liver disease. Taken together, our results show that LinSTZ mice fed a HFD did not lead to a more robust model of MS-induced CKD, protected against kidney injury, but inducing liver damage. More studies are necessary to understand the kidney protective mechanisms of HFD when superimposed with hypertension and type 1 diabetes.
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页数:15
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