Presence of Streptococcus pyogenes in the throat in invasive Group A Streptococcal disease: a prospective two-year study in two health districts, Finland

被引：6

作者：

Kailankangas, Ville ^{[1
,2
]}

Vilhonen, Johanna ^{[3
,4
,5
]}

Grondahl-Yli-Hannuksela, Kirsi ^{[6
]}

Rantakokko-Jalava, Kaisu ^{[7
]}

Seiskari, Tapio ^{[8
]}

Auranen, Kari ^{[9
,10
]}

Lonnqvist, Emilia ^{[6
]}

Virolainen, Mirva ^{[6
]}

Hyyrylainen, Hanne-Leena ^{[11
]}

Oksi, Jarmo ^{[3
,4
]}

Syrjanen, Jaana ^{[1
,2
]}

Vuopio, Jaana ^{[6
,7
,11
]}

机构：

[1] Tampere Univ Hosp, Dept Internal Med, Infect Dis Unit, Tampere, Finland

[2] Tampere Univ, Fac Med & Hlth Technol, Tampere, Finland

[3] Turku Univ Hosp, Dept Infect Dis, Turku, Finland

[4] Univ Turku, Fac Med, Turku, Finland

[5] Univ Turku, Doctoral Programme Clin Res DPCR, Turku, Finland

[6] Univ Turku, Inst Biomed, Turku, Finland

[7] Turku Univ Hosp, Dept Clin Microbiol, Lab Div, Turku, Finland

[8] Fimlab Labs, Dept Clin Microbiol, Tampere, Finland

[9] Univ Turku, Dept Math & Stat, Dept Clin Med, Turku, Finland

[10] Univ Turku, Dept Clin Med, Turku, Finland

[11] Finnish Inst Hlth & Welf THL, Expert Microbiol, Helsinki, Finland

来源：

INFECTIOUS DISEASES | 2023年 / 55卷 / 06期

基金：

芬兰科学院;

关键词：

Group A Streptococcus; invasive infection; incidence; portal of entry; throat carriage; EPIDEMIOLOGY; INFECTIONS; BACTEREMIA; VIRULENCE; RISK;

D O I：

10.1080/23744235.2023.2192287

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Purpose: Streptococcus pyogenes (Group A Streptococcus, GAS) is an important human pathogen that can cause severe invasive (iGAS) infections. Throat carriage has been assumed to possibly lead to hematogenous seeding. Retrospective studies may estimate the incidence of throat carriage in iGAS patients inaccurately. In this study we aimed to gather data on the presence of GAS in the throat among iGAS patients in a prospective setting. Methods: We conducted a prospective clinical study covering iGAS infections in adult patients in two university hospitals in Finland from June 2018 to July 2020. Recruited patients' throats were swabbed for culture and isothermal amplification tests (IAT) to search for GAS. The study was registered at ClinicalTrials.gov as ID NCT03507101. Results: We enrolled 45 patients. Throat swabs were obtained from 39/45 (87%) patients. Ten patients (22%) had a positive IAT for GAS. They were statistically significantly more likely to be male (9/10 [90%] vs 13/29 [45%], p = .024). Several different emm types caused the iGAS infections. Conclusions: GAS was frequently observed in throat swabs of patients with iGAS infection. This may suggest that hematogenous seeding from the nasopharynx is a possible portal of entry.

引用

页码：405 / 414

页数：10

共 34 条

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