Prophylactic versus reactive feeding approach in patients undergoing adjuvant radiation therapy for oral cavity squamous cell carcinoma: A propensity score matched-pair analysis

被引：0

作者：

Ghosh Laskar, Sarbani ^{[1
,5
]}

Sinha, Shwetabh ^{[1
]}

Gupta, Meetakshi ^{[1
]}

Karmakar, Shreyasee ^{[1
]}

Nivedha, J. Meenakshi ^{[1
]}

Kannan, Sadhana ^{[2
]}

Budrukkar, Ashwini ^{[1
]}

Swain, Monali ^{[1
]}

Kumar, Anuj ^{[1
]}

Gupta, Tejpal ^{[1
]}

Murthy, Vedang ^{[1
]}

Chaukar, Devendra ^{[3
]}

Pai, Prathamesh ^{[3
]}

Chaturvedi, Pankaj ^{[3
]}

Pantvaidya, Gouri ^{[3
]}

Nair, Deepa ^{[3
]}

Nair, Sudhir ^{[3
]}

Thiagarajan, Shivakumar ^{[3
]}

Deshmukh, Anuja ^{[3
]}

Noronha, Vanita ^{[4
]}

Patil, Vijay ^{[4
]}

Joshi, Amit ^{[4
]}

Prabhash, Kumar ^{[4
]}

Agarwal, Jai Prakash ^{[1
]}

机构：

[1] Homi Bhabha Natl Inst, Tata Mem Ctr, Dept Radiat Oncol, Mumbai, Maharashtra, India

[2] Homi Bhabha Natl Inst, Tata Mem Ctr, Clin Res Secretariat, Mumbai, Maharashtra, India

[3] Homi Bhabha Natl Inst, Tata Mem Ctr, Dept Head & Neck Surg, Mumbai, Maharashtra, India

[4] Homi Bhabha Natl Inst, Tata Mem Ctr, Dept Med Oncol, Mumbai, Maharashtra, India

[5] Homi Bhabha Natl Inst, Tata Mem Ctr, Dept Radiat Oncol, Head & Neck Dis Management Grp, Mumbai 400012, Maharashtra, India

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2023年 / 45卷 / 05期

关键词：

nasogastric tube; oral cancers; percutaneous endoscopic gastrostomy; prophylactic feeding tube; reactive feeding; PERCUTANEOUS ENDOSCOPIC GASTROSTOMY; RANDOMIZED CONTROLLED-TRIAL; NECK-CANCER; ADVANCED HEAD; CHEMORADIATION THERAPY; RADIOTHERAPY; IMPACT; CHEMORADIOTHERAPY; TUBE; COMPLICATIONS;

D O I：

10.1002/hed.27336

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

BackgroundTo assess the efficacy of prophylactic versus reactive feeding strategy in oral cavity squamous cell carcinoma (OCSCC) patients receiving adjuvant radiation therapy (RT). MethodsThis was a post hoc analysis of patients of OCSCC enrolled in a randomized trial comparing three adjuvant strategies. In this trial, till 2010, a prophylactic feeding approach was followed for all patients. Since January 2011, a reactive feeding approach was followed. ResultsTwo hundred and sixty-eight in each cohort (total n = 526) were eligible for analysis after propensity score matching. At 6 weeks post-RT completion, the median weight loss in the prophylactic versus reactive cohort was 5 versus 3 kg, p = 0.002. At all other time points until 1 year, the median weight loss was lesser in reactive than in the prophylactic cohort. ConclusionsA reactive feeding tube approach should be preferred for OCSCC receiving adjuvant RT.

引用

页码：1226 / 1236

页数：11

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