Non-invasive vagus nerve stimulation in a hungry state decreases heart rate variability

被引:7
作者
Altinkaya, Zeynep [1 ]
Ozturk, Lina [2 ]
Buyukguduk, Ilkim [3 ]
Yanik, Huseyin [4 ]
Yilmaz, Dilan Deniz [5 ]
Yar, Bercem [3 ]
Degirmenci, Evren [4 ,6 ]
Dal, Ugur [5 ]
Veldhuizen, Maria Geraldine [3 ,6 ,7 ]
机构
[1] Mersin Univ, Hlth Sci Inst, Mersin, Turkiye
[2] Mersin Univ, Fac Med, Mersin, Turkiye
[3] Mersin Univ, Fac Sci & Letters, Dept Psychol, Mersin, Turkiye
[4] Mersin Univ, Fac Engn, Dept Elect & Elect Engn, Mersin, Turkiye
[5] Mersin Univ, Fac Med, Dept Physiol, Mersin, Turkiye
[6] Mersin Univ, Biotechnol Res & Applicat Ctr, Mersin, Turkiye
[7] Mersin Univ, Fac Med, Dept Anat, Mersin, Turkiye
关键词
Transcutaneous auricular vagus nerve; stimulation; Food reward; Energy expenditure; Electrogastrogram; Heart -rate variability; Wanting; WEIGHT-LOSS; MOTILITY; OBESITY; VAGAL;
D O I
10.1016/j.physbeh.2022.114016
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Vagus nerve signals from the gut to brain carry information about nutrients and drive food reward. Such signals are disrupted by consuming large amounts of high-calorie foods, necessitating greater food intake to elicit a similar neural response. Non-invasive vagus nerve stimulation (nVNS) via a branch innervating the ear is a candidate treatment for obesity in humans. There is disagreement on the optimal location of nVNS in the ear for experimental and clinical studies. There are also no studies comparing nVNS in hungry and post-prandial states. We aimed to compare ear position(s) for nVNS and explore the effects of nVNS during hungry and post-prandial states on proxies for autonomic outflow (heart-rate variability) and efferent metabolism (gastric wave frequency and resting energy expenditure).In a within-subject design, 14 participants (10 women, on average 29.4 +/- 6.7 years old) received nVNS in four different locations (cymba conchae, tragus, earlobe, or tragus AND cymba conchae) on separate days. In each session, participants were asked to consume a palatable chocolate flavored milk. With electrography on the abdomen and indirect calorimetry in a canopy, we measured electro-cardiogram, electro-gastrogram and resting energy expenditure for 15 min before and at least 35 min after consumption of the palatable drink. We also collected ratings of the palatable drink and internal and other states.Pre-drink consumption (in a hungry state) we observed no differences in the effect of location of acute nVNS on resting energy expenditure and gastric wave measures. However, nVNS in cymba conchae decreases heartrate variability (relative to sham) and ratings of how much participants want to consume the drink (relative to tragus AND cymba conchae and a trend relative to sham). After drink consumption and with continued nVNS, gastric wave frequency is unchanged, and resting energy expenditure increases regardless of stimulation location. Heart-rate variability decreases in all locations, except cymba conchae. We also observe a trend for an increase in gastric wave amplitude in late post-drink consumption time-points in cymba conchae. We observe no support for the combined stimulation of tragus AND cymba conchae being more effective than either of the individual locations.These results suggest that nVNS in the cymba conchae in a hungry state has a similar acute effect on vagal tone as food consumption: to decrease heart rate variability. This effect then negates the usual postprandial effects of a decrease in heart rate variability as seen in the other nVNS locations. These preliminary observations suggest that nVNS in cymba conchae may act primarily on vagal afferent autonomic (and only modestly on metabolic output) in a similar way as food consumption does.
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页数:12
相关论文
共 53 条
[1]   Modulation of visual processing of food by transcutaneous vagus nerve stimulation (tVNS) [J].
Alicart, Helena ;
Heldmann, Marcus ;
Goettlich, Martin ;
Obst, Martina A. ;
Tittgemeyer, Marc ;
Muente, Thomas F. .
BRAIN IMAGING AND BEHAVIOR, 2021, 15 (04) :1886-1897
[2]   Transcutaneous Auricular Vagus Nerve Stimulation-Paired Rehabilitation for Oromotor Feeding Problems in Newborns: An Open-Label Pilot Study [J].
Badran, Bashar W. ;
Jenkins, Dorothea D. ;
Cook, Daniel ;
Thompson, Sean ;
Dancy, Morgan ;
DeVries, William H. ;
Mappin, Georgia ;
Summers, Philipp ;
Bikson, Marom ;
George, Mark S. .
FRONTIERS IN HUMAN NEUROSCIENCE, 2020, 14
[3]   Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS): Technique, Targeting, and Considerations [J].
Badran, Bashar W. ;
Yu, Alfred B. ;
Adair, Devin ;
Mappin, Georgia ;
DeVries, William H. ;
Jenkins, Dorothea D. ;
George, Mark S. ;
Bikson, Marom .
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2019, (143)
[4]   Tragus or cymba conchae? Investigating the anatomical foundation of transcutaneous auricular vagus nerve stimulation (taVNS) [J].
Badran, Bashar W. ;
Brown, Joshua C. ;
Dowdle, Logan T. ;
Mithoefer, Oliver J. ;
LaBate, Nicholas T. ;
Coatsworth, James ;
DeVries, William H. ;
Austelle, Christopher W. ;
McTeague, Lisa M. ;
Yu, Alfred ;
Bikson, Marom ;
Jenkins, Dorothea D. ;
George, Mark S. .
BRAIN STIMULATION, 2018, 11 (04) :947-948
[5]  
Beasley B.M., 2013, UNDERSTANDING EKGS P
[6]   Vagal and hormonal gut-brain communication: from satiation to satisfaction [J].
Berthoud, H. -R. .
NEUROGASTROENTEROLOGY AND MOTILITY, 2008, 20 :64-72
[7]  
Bodenlos Jamie S, 2007, J Diabetes Sci Technol, V1, P771
[8]  
Bouchequet P., 2018, MED SOMMEIL, V15, P48, DOI DOI 10.1016/J.MSOM.2018.01.130
[9]  
Bugajski AJ, 2007, J PHYSIOL PHARMACOL, V58, P5
[10]   Weight loss associated with vagus nerve stimulation [J].
Burneo, JG ;
Faught, E ;
Knowlton, R ;
Morawetz, R ;
Kuzniecky, R .
NEUROLOGY, 2002, 59 (03) :463-464