Impact of carrier hydrophilicity on solid self nano-emulsifying drug delivery system and self nano-emulsifying granule system

被引：12

作者：

Kim, Jung Suk ^{[1
]}

Din, Fakhar Ud ^{[2
]}

Cho, Hyuk Jun ^{[1
]}

Choi, Yoo Jin ^{[1
]}

Woo, Mi Ran ^{[1
]}

Cheon, Seunghyun ^{[1
]}

Ji, Sang Hun ^{[1
]}

Park, Seonghyeon ^{[1
]}

Youn, Yu Seok ^{[3
]}

Oh, Kyung Taek ^{[4
]}

Lim, Soo-Jeong ^{[5
]}

Jin, Sung Giu ^{[6
]}

Choi, Han-Gon ^{[1
]}

机构：

[1] Hanyang Univ, Coll Pharm, 55 Hanyangdaehak Ro, Ansan 15588, South Korea

[2] Quaid I Azam Univ, Dept Pharm, Islamabad 45320, Pakistan

[3] Sungkyunkwan Univ, Sch Pharm, 300 Cheoncheon Dong, Suwon 440746, South Korea

[4] Chung Ang Univ, Coll Pharm, 221 Heuksuk Dong, Seoul 156756, South Korea

[5] Sejong Univ, Dept Biosci & Biotechnol, 98 Gunja Dong, Seoul 143747, South Korea

[6] Dankook Univ, Dept Pharmaceut Engn, 119 Dandae Ro, Cheonan 31116, South Korea

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2023年 / 648卷

基金：

新加坡国家研究基金会;

关键词：

Hydroxypropyl-I3-cyclodextrin; Self nano-emulsifying granule system; Solid self nano-emulsifying drug delivery system; Micromeritic property; Crystallinity; Oral bioavailability; LIPID CARRIERS; NANOPARTICLES;

D O I：

10.1016/j.ijpharm.2023.123578

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The purpose of this study was to investigate the impact of carrier hydrophilicity on solid self nano-emulsifying drug delivery system (SNEDDS) and self nano-emulsifying granule system (SEGS). The mesoporous calcium silicate (Ca-silicate) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD) were utilised as hydrophobic carrier and hydrophilic carrier, respectively. The liquid SNEDDS formulation, composed of Tween80/Kollipohr EL/corn oil (35/50/15%) with 31% (w/w) dexibuprofen, was spray-dried and fluid-bed granulated together with Avicel using Ca-silicate or HP- beta-CD as a solid carrier, producing four different solid SNEDDS and SEGS formulations. Unlike the Ca-silicate-based systems, spherical shape and aggregated particles were shown in HP-beta-CD-based solid SNEDDS and SEGS, respectively. Molecular interaction was detected between Ca-silicate and the drug; though, none was shown between HP-beta-CD and the drug. Each system prepared with either carrier gave no significant differences in micromeritic properties, crystallinity, droplet morphology, size, dissolution and oral bioavailability in rats. However, the HP-beta-CD-based system more significantly improved the drug solubility than did the Ca-silicate-based system. Therefore, both carriers hardly affected the properties of both solid SNEDDS and SEGS; though, there were differences in the aspect of appearance, molecular interaction and solubility.

引用

页数：11

共 39 条

[1] Issues currently complicating the risk assessment of synthetic amorphous silica (SAS) nanoparticles after oral exposure [J].