How I treat posttransplant lymphoproliferative disorder

被引：14

作者：

Amengual, Jennifer E. ^{[1
,2
]}

Pro, Barbara ^{[1
]}

机构：

[1] Columbia Univ, Herbert Irving Comprehens Canc Ctr, Div Hematol & Oncol, New York, NY USA

[2] Columbia Univ, Herbert Irving Comprehens Canc Ctr, Div Hematol & Oncol, 161 Ft Washington Ave,Garden Level, New York, NY 10032 USA

来源：

BLOOD | 2023年 / 142卷 / 17期

关键词：

SOLID-ORGAN TRANSPLANT; T-CELL THERAPY; BRENTUXIMAB VEDOTIN SGN-35; ADOPTIVE IMMUNOTHERAPY; AMERICAN SOCIETY; 2ND-LINE THERAPY; DONOR LEUKOCYTES; LYMPHOMA; DISEASE; SURVIVAL;

D O I：

10.1182/blood.2023020075

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Posttransplant lymphoproliferative disorder (PTLD) is an important and potentially life-threatening complication of solid organ transplant and hematopoietic stem cell transplant (HSCT). Given the heterogeneity of PTLD and the risk of infectious complications in patients with immunosuppression, the treatment of this disease remains challenging. Monomorphic PTLD and lymphoma of B-cell origin account for the majority of cases. Treatment strategies for PTLD consist of response-adapted, risk-stratified methods using immunosuppression reduction, immunotherapy, and/or chemotherapy. With this approach, similar to 25% of the patients do not need chemotherapy. Outcomes for patients with high risk or those who do not respond to frontline therapies remain dismal, and novel treatments are needed in this setting. PTLD is associated with Epstein-Barr virus (EBV) infection in 60% to 80% of cases, making EBV-directed therapy an attractive treatment modality. Recently, the introduction of adoptive immunotherapies has become a promising option for refractory cases; hopefully, these treatment strategies can be used as earlier lines of therapy in the future.

引用

页码：1426 / 1437

页数：12

共 84 条

[71]

Schroers-Martin J, 2022, Blood, V140, P172

[72] Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective in HIV-associated B-cell non-Hodgkin lymphoma [J].

Sparano, Joseph A. ;

Lee, Jeannette Y. ;

Kaplan, Lawrence D. ;

Levine, Alexandra M. ;

Ramos, Juan Carlos ;

Ambinder, Richard F. ;

Wachsman, William ;

Aboulafia, David ;

Noy, Ariela ;

Henry, David H. ;

Von Roenn, Jamie ;

Dezube, Bruce J. ;

Remick, Scot C. ;

Shah, Manisha H. ;

Leichman, Lawrence ;

Ratner, Lee ;

Cesarman, Ethel ;

Chadburn, Amy ;

Mitsuyasu, Ronald .

BLOOD, 2010, 115 (15) :3008-3016

[73] AGGRESSIVE TREATMENT FOR POSTCARDIAC TRANSPLANT LYMPHOPROLIFERATION [J].

SWINNEN, LJ ;

MULLEN, GM ;

CARR, TJ ;

COSTANZO, MR ;

FISHER, RI .

BLOOD, 1995, 86 (09) :3333-3340

[74] Prospective study of sequential reduction in immunosuppression, interferon alpha-2b, and chemotherapy for posttransplantation lymphoproliferative disorder [J].

Swinnen, Lode J. ;

LeBlanc, Michael ;

Grogan, Thomas M. ;

Gordon, Leo I. ;

Stiff, Patrick J. ;

Miller, Alan M. ;

Kasamon, Yvette ;

Miller, Thomas P. ;

Fisher, Richard I. .

TRANSPLANTATION, 2008, 86 (02) :215-222

[75] International Prognostic Index, Type of Transplant and Response to Rituximab Are Key Parameters to Tailor Treatment in Adults With CD20-Positive B Cell PTLD: Clues From the PTLD-1 Trial [J].

Trappe, R. U. ;

Choquet, S. ;

Dierickx, D. ;

Mollee, P. ;

Zaucha, J. M. ;

Dreyling, M. H. ;

Duehrsen, U. ;

Tarella, C. ;

Shpilberg, O. ;

Sender, M. ;

Salles, G. ;

Morschhauser, F. ;

Jaccard, A. ;

Lamy, T. ;

Reinke, P. ;

Neuhaus, R. ;

Lehmkuhl, H. ;

Horst, H. A. ;

Leithaeuser, M. ;

Schlattmann, P. ;

Anagnostopoulos, I. ;

Raphael, M. ;

Riess, H. ;

Leblond, V. ;

Oertel, S. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2015, 15 (04) :1091-1100

[76] Sequential treatment with rituximab followed by CHOP chemotherapy in adult B-cell post-transplant lymphoproliferative disorder (PTLD): the prospective international multicentre phase 2 PTLD-1 trial [J].

Trappe, Ralf ;

Oertel, Stephan ;

Leblond, Veronique ;

Mollee, Peter ;

Sender, Monica ;

Reinke, Petra ;

Neuhaus, Ruth ;

Lehmkuhl, Hans ;

Horst, Heinz August ;

Salles, Gilles ;

Morschhauser, Franck ;

Jaccard, Arnaud ;

Lamy, Thierry ;

Leithaeuser, Malte ;

Zimmermann, Heiner ;

Anagnostopoulos, Ioannis ;

Raphael, Martine ;

Riess, Hanno ;

Choquet, Sylvain .

LANCET ONCOLOGY, 2012, 13 (02) :196-206

[77] Response to Rituximab Induction Is a Predictive Marker in B-Cell Post-Transplant Lymphoproliferative Disorder and Allows Successful Stratification Into Rituximab or R-CHOP Consolidation in an International, Prospective, Multicenter Phase II Trial [J].

Trappe, Ralf U. ;

Dierickx, Daan ;

Zimmermann, Heiner ;

Morschhauser, Franck ;

Mollee, Peter ;

Zaucha, Jan M. ;

Dreyling, Martin H. ;

Duehrsen, Ulrich ;

Reinke, Petra ;

Verhoef, Gregor ;

Subklewe, Marion ;

Huettmann, Andreas ;

Tousseyn, Thomas ;

Salles, Gilles ;

Kliem, Volker ;

Hauser, Ingeborg A. ;

Tarella, Corrado ;

Van Den Neste, Eric ;

Gheysens, Olivier ;

Anagnostopoulos, Ioannis ;

Leblond, Veronique ;

Riess, Hanno ;

Choquet, Sylvain .

JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (05) :536-+

[78] Salvage therapy for relapsed posttransplant lymphoproliferative disorders (PTLD) with a second progression of PTLD after upfront chemotherapy:: The role of single-agent rituximab [J].

Trappe, Ralif U. ;

Choquet, Sylvain ;

Reinke, Peira ;

Dreyling, Martin ;

Mergenthaler, Hans-Gunther ;

Jager, Ulrich ;

Kebelmann-Betzing, Christian ;

Jonas, Sven ;

Lehmkuhl, Hans ;

Anagnostopoulos, Ioannis ;

Lebland, Veronique ;

Hetzer, Roland ;

Dorken, Bernd ;

Riess, Hanno ;

Oertel, Stephan .

TRANSPLANTATION, 2007, 84 (12) :1708-1712

[79] The changing face of adult posttransplant lymphoproliferative disorder: Changes in histology between 1999 and 2013 [J].

Tsai, Donald E. ;

Bagley, Stephen ;

Reshef, Ran ;

Shaked, Abraham ;

Bloom, Roy D. ;

Ahya, Vivek ;

Goldberg, Lee ;

Chung, Albert ;

Debonera, Fotini ;

Schuster, Stephen J. ;

Huntington, Scott F. .

AMERICAN JOURNAL OF HEMATOLOGY, 2018, 93 (07) :874-881

[80] Occurrence and prognostic relevance of CD30 expression in post-transplant lymphoproliferative disorders [J].

Vase, Maja Olholm ;

Maksten, Eva Futtrup ;

Bendix, Knud ;

Hamilton-Dutoit, Stephen ;

Andersen, Claus ;

Moller, Michael Boe ;

Sorensen, Soren Schwartz ;

Jespersen, Bente ;

Kampmann, Jan ;

Sondergard, Esben ;

Nielsen, Patricia Switten ;

D'amore, Francesco .

LEUKEMIA & LYMPHOMA, 2015, 56 (06) :1677-1685

← 1 2 3 4 5 6 7 8 9 →