Exploring the Potential of the Corpus Callosum Area as a Predictive Marker for Impaired Information Processing in Multiple Sclerosis

被引:3
作者
Akaike, Shun [1 ]
Okamoto, Tomoko [1 ]
Kurosawa, Ryoji [1 ]
Onodera, Nozomi [1 ]
Lin, Youwei [1 ]
Sato, Wakiro [2 ]
Yamamura, Takashi [2 ]
Takahashi, Yuji [1 ]
机构
[1] Natl Ctr Neurol & Psychiat, Dept Neurol, Tokyo 1878551, Japan
[2] Natl Ctr Neurol & Psychiat, Dept Immunol, Tokyo 1878551, Japan
关键词
multiple sclerosis; cognitive impairment; magnetic resonance imaging; COGNITIVE IMPAIRMENT; ATROPHY; DYSFUNCTION;
D O I
10.3390/jcm12216948
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Early cognitive impairment (CI) detection is crucial in multiple sclerosis (MS). However, it can progress silently regardless of relapse activity and reach an advanced stage. We aimed to determine whether the corpus callosum area (CCA) is a sensitive and feasible marker for CI in MS compared to other neuroimaging markers. We assessed cognitive function in 77 MS patients using the Symbol Digit Modalities Test, Paced Auditory Serial Additions Task, Wechsler Adult Intelligence Scale-IV, and Wechsler Memory Scale-Revised. The neuroimaging markers included manually measured CCA, two diffusion tensor imaging markers, and nine volumetric measurements. Apart from volumes of the hippocampus and cerebellum, ten markers showed a significant correlation with all neuropsychological tests and significant differences between the groups. The normalized CCA demonstrated a moderate-to-strong correlation with all neuropsychological tests and successfully differentiated between the CI and cognitively normal groups with 80% sensitivity and 83% specificity. The marker had a large area under the curve and a high Youden index (0.82 and 0.63, respectively) and comparability with established cognitive markers. Therefore, the normalized CCA may serve as a reliable marker for CI in MS and can be easily implemented in clinical practice, providing a supportive diagnostic tool for CI in MS.
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页数:11
相关论文
共 34 条
[1]   Basal ganglia, thalamus and neocortical atrophy predicting slowed cognitive processing in multiple sclerosis [J].
Batista, Sonia ;
Zivadinov, Robert ;
Hoogs, Marietta ;
Bergsland, Niels ;
Heininen-Brown, Mari ;
Dwyer, Michael G. ;
Weinstock-Guttman, Bianca ;
Benedict, Ralph H. B. .
JOURNAL OF NEUROLOGY, 2012, 259 (01) :139-146
[2]   Siponimod and Cognition in Secondary Progressive Multiple Sclerosis EXPAND Secondary Analyses [J].
Benedict, Ralph H. B. ;
Tomic, Davorka ;
Cree, Bruce A. ;
Fox, Robert ;
Giovannoni, Gavin ;
Bar-Or, Amit ;
Gold, Ralf ;
Vermersch, Patrick ;
Pohlmann, Harald ;
Wright, Ian ;
Karlsson, Goril ;
Dahlke, Frank ;
Wolf, Christian ;
Kappos, Ludwig .
NEUROLOGY, 2021, 96 (03) :E376-E386
[3]   Brief International Cognitive Assessment for MS (BICAMS): international standards for validation [J].
Benedict, Ralph H. B. ;
Amato, Maria Pia ;
Boringa, Jan ;
Brochet, Bruno ;
Foley, Fred ;
Fredrikson, Stan ;
Hamalainen, Paivi ;
Hartung, Hans ;
Krupp, Lauren ;
Penner, Iris ;
Reder, Anthony T. ;
Langdon, Dawn .
BMC NEUROLOGY, 2012, 12
[4]   Risk factors for and management of cognitive dysfunction in multiple sclerosis [J].
Benedict, Ralph H. B. ;
Zivadinov, Robert .
NATURE REVIEWS NEUROLOGY, 2011, 7 (06) :332-342
[5]   Prediction of neuropsychological impairment in multiple sclerosis - Comparison of conventional magnetic resonance imaging measures of atrophy and lesion burden [J].
Benedict, RHB ;
Weinstock-Guttman, B ;
Fishman, I ;
Sharma, J ;
Tjoa, CW ;
Bakshi, R .
ARCHIVES OF NEUROLOGY, 2004, 61 (02) :226-230
[6]   Attention and processing speed performance in multiple sclerosis is mostly related to thalamic volume [J].
Bisecco, Alvino ;
Stamenova, Svetlana ;
Caiazzo, Giuseppina ;
d'Ambrosio, Alessandro ;
Sacco, Rosaria ;
Docimo, Renato ;
Esposito, Sabrina ;
Cirillo, Mario ;
Esposito, Fabrizio ;
Bonavita, Simona ;
Tedeschi, Gioacchino ;
Gallo, Antonio .
BRAIN IMAGING AND BEHAVIOR, 2018, 12 (01) :20-28
[7]   Progressive multiple sclerosis, cognitive function, and quality of life [J].
Chow, Helene Hojsgaard ;
Schreiber, Karen ;
Magyari, Melinda ;
Ammitzboll, Cecilie ;
Bornsen, Lars ;
Christensen, Jeppe Romme ;
Ratzer, Rikke ;
Sorensen, Per Soelberg ;
Sellebjerg, Finn .
BRAIN AND BEHAVIOR, 2018, 8 (02)
[8]   Silent progression in disease activity-free relapsing multiple sclerosis [J].
Cree, Bruce A. C. ;
Hollenbach, Jill A. ;
Bove, Riley ;
Kirkish, Gina ;
Sacco, Simone ;
Caverzasi, Eduardo ;
Bischof, Antje ;
Gundel, Tristan ;
Zhu, Alyssa H. ;
Papinutto, Nico ;
Stern, William A. ;
Bevan, Carolyn ;
Romeo, Andrew ;
Goodin, Douglas S. ;
Gelfand, Jeffrey M. ;
Graves, Jennifer ;
Green, Ari J. ;
Wilson, Michael R. ;
Zamvil, Scott S. ;
Zhao, Chao ;
Gomez, Refujia ;
Ragan, Nicholas R. ;
Rush, Gillian Q. ;
Barba, Patrick ;
Santaniello, Adam ;
Baranzini, Sergio E. ;
Oksenberg, Jorge R. ;
Henry, Roland G. ;
Hauser, Stephen L. .
ANNALS OF NEUROLOGY, 2019, 85 (05) :653-666
[9]   Disconnection as a mechanism for cognitive dysfunction in multiple sclerosis [J].
Dineen, R. A. ;
Vilisaar, J. ;
Hlinka, J. ;
Bradshaw, C. M. ;
Morgan, P. S. ;
Constantinescu, C. S. ;
Auer, D. P. .
BRAIN, 2009, 132 :239-249
[10]  
Figueira Fernando Faria Andrade, 2007, Arq. Neuro-Psiquiatr., V65, P931