Highlights from the 1st European cancer dependency map symposium and workshop

被引：2

作者：

Trastulla, Lucia ^{[1
]}

Savino, Aurora ^{[1
]}

Beltrao, Pedro ^{[2
]}

Ciriano, Isidro Cortes ^{[3
]}

Fenici, Peter ^{[4
]}

Garnett, Mathew J. J. ^{[5
]}

Guerini, Ilaria ^{[1
]}

Bigas, Nuria Lopez ^{[6
]}

Mattaj, Iain ^{[1
]}

Petsalaki, Evangelia

Riva, Laura ^{[7
]}

Tape, Christopher J. J. ^{[8
]}

Sharma, Sumana ^{[9
]}

Vazquez, Francisca ^{[10
,11
]}

Iorio, Francesco ^{[1
]}

机构：

[1] Human Technopole, Milan, Italy

[2] Swiss Fed Inst Technol, Inst Mol Syst Biol, Zurich, Switzerland

[3] EMBL European Bioinformat Inst, Cambridge, England

[4] AstraZeneca, Milan, Italy

[5] Wellcome Sanger Inst, Cambridge, England

[6] Bioimed Res Inst, Barcelona, Spain

[7] Nerviano Med Sci, Milan, Italy

[8] UCL, London, England

[9] Univ Oxford, Oxford, England

[10] Broad Inst MIT & Harvard, Cambridge, MA USA

[11] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA

来源：

FEBS LETTERS | 2023年 / 597卷 / 15期

关键词：

cancer; dependency map; large scale; screens; symposium; workshop; computational biology; CRISPR; cancer models; drug discovery;

D O I：

10.1002/1873-3468.14699

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The systematic identification of tumour vulnerabilities through perturbational experiments on cancer models, including genome editing and drug screens, is playing a crucial role in combating cancer. This collective effort is known as the Cancer Dependency Map (DepMap). The 1st European Cancer Dependency Map Symposium (EuroDepMap), held in Milan last May, featured talks, a roundtable discussion, and a poster session, showcasing the latest discoveries and future challenges related to the DepMap. The symposium aimed to facilitate interactions among participants across Europe, encourage idea exchange with leading experts, and present their work and future projects. Importantly, it sparked discussions on future endeavours, such as screening more complex cancer models and accounting for tumour evolution.

引用

页码：1921 / 1927

页数：7

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