Relationship of Apolipoprotein E with Alzheimer's Disease and Other Neurological Disorders: An Updated Review

被引：10

作者：

Lou, Tianwen ^{[1
,2
]}

Tao, Borui ^{[1
,2
]}

Chen, Ming ^{[2
]}

机构：

[1] Anhui Med Univ, Clin Med Coll 1, Hefei, Peoples R China

[2] Anhui Med Univ, Sch Basic Med Sci, Dept Pharmacol, Hefei, Peoples R China

来源：

NEUROSCIENCE | 2023年 / 514卷

关键词：

Apolipoprotein E; Alzheimer?s disease; Ab pathology; cerebral amyloid angiopathy; neurodegenerative disease; Major depressive disorder; TRAUMATIC BRAIN-INJURY; INCIDENT DEPRESSIVE SYMPTOMS; CEREBRAL AMYLOID ANGIOPATHY; DIABETES-MELLITUS; GENE POLYMORPHISM; APOE EPSILON-4; BETA; TAU; METAANALYSIS; BURDEN;

D O I：

10.1016/j.neuroscience.2023.01.032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) and other neurodegenerative diseases, for which there is no effective cure, cause great social burden. Apolipoprotein E (APOE) is an important lipid transporter, which has been shown to have a close relationship with AD and other neurological disorders in an increasing number of studies, sug-gesting its potential as a therapeutic target. In this review, we summarize the recent advances in clinical and basic research on the role of APOE in the pathogenesis of multiple neurological diseases, with an emphasis on the new associations between APOE and AD, and between APOE and depression. The progress of APOE research in Parkinson's disease (PD) and some other neurological diseases is briefly discussed.(c) 2023 IBRO. Published by Else-vier Ltd. All rights reserved.

引用

页码：123 / 140

页数：18

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