Matrix metalloproteinase-7 and claudin-7 as novel identified therapeutic targets for restoration of intestinal epithelial barrier in inflammatory bowel diseases

被引：1

作者：

Hankan, Sunisa ^{[1
]}

Pongkorpsakol, Pawin ^{[1
,2
]}

机构：

[1] Lab Epithelial Tight Junct Pathophysiol, Bangkok, Thailand

[2] Chulabhorn Royal Acad, Princess Srisavangavadhana Coll Med, Bangkok, Thailand

来源：

TISSUE BARRIERS | 2024年 / 12卷 / 01期

关键词：

Matrix metalloproteinase 7 (MMP-7); claudin-7; inflammatory bowel diseases (IBD); colitis; Tight junction;

D O I：

10.1080/21688370.2023.2182117

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Intestinal tight junction disruption and mucosal immune dysregulation contribute to pathogenesis and progression of inflammatory bowel diseases (IBD). A proteolytic enzyme matrix metalloproteinase 7 (MMP-7), which is highly expressed in intestinal tissue, is implicated to IBD and other immune overactivation-associated diseases. In the issue of the Frontiers in Immunology, Ying Xiao and colleagues demonstrate that MMP-7-mediated claudin-7 degradation promotes IBD pathogenesis and disease progression. Therefore, inhibition of MMP-7 enzymatic activity can be a therapeutic strategy for the treatment of IBD.

引用

页数：3

共 9 条

[1] EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier [J].

Higashi, Tomohito ;

Saito, Akira C. ;

Fukazawa, Yugo ;

Furuse, Mikio ;

Higashi, Atsuko Y. ;

Ono, Masahiro ;

Chiba, Hideki .

JOURNAL OF CELL BIOLOGY, 2023, 222 (01)

[2] The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair [J].

Kuo, Wei-Ting ;

Zuo, Li ;

Odenwald, Matthew A. ;

Madha, Shariq ;

Singh, Gurminder ;

Gurniak, Christine B. ;

Abraham, Clara ;

Turner, Jerrold R. .

GASTROENTEROLOGY, 2021, 161 (06) :1924-1939

[3] An Unexplored Role for MMP-7 (Matrix Metalloproteinase-7) in Promoting Gut Permeability After Ischemic Stroke [J].

Larochelle, Jonathan ;

Yang, Changjun ;

Liu, Lei ;

Candelario-Jalil, Eduardo .

STROKE, 2022, 53 (10) :3238-3242

[4] Roles of matrix metalloproteinase-7 (MMP-7) in cancer [J].

Liao, Hai-Yang ;

Da, Chao-Ming ;

Liao, Bei ;

Zhang, Hai-Hong .

CLINICAL BIOCHEMISTRY, 2021, 92 :9-18

[5] Occludin knockdown is not sufficient to induce transepithelial macromolecule passage [J].

Richter, Jan F. ;

Hildner, Markus ;

Schmauder, Ralf ;

Turner, Jerrold R. ;

Schumann, Michael ;

Reiche, Juliane .

TISSUE BARRIERS, 2019, 7 (02)

[6] The fundamental basis of inflammatory bowel disease [J].

Strober, Warren ;

Fuss, Ivan ;

Mannon, Peter .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (03) :514-521

[7] TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis [J].

Su, Liping ;

Nalle, Sam C. ;

Shen, Le ;

Turner, Emily S. ;

Singh, Gurminder ;

Breskin, Lydia A. ;

Khramtsova, Ekaterina A. ;

Khramtsova, Galina ;

Tsai, Pei-Yun ;

Fu, Yang-Xin ;

Abraham, Clara ;

Turner, Jerrold R. .

GASTROENTEROLOGY, 2013, 145 (02) :407-415

[8] Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice [J].

Tanaka, Hiroo ;

Takechi, Maki ;

Kiyonari, Hiroshi ;

Shioi, Go ;

Tamura, Atsushi ;

Tsukita, Sachiko .

GUT, 2015, 64 (10) :1529-U209

[9] Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7 [J].

Xiao, Ying ;

Lian, Haifeng ;

Zhong, Xiaoying S. ;

Krishnachaitanya, Srikruthi S. ;

Cong, Yingzi ;

Dashwood, Roderick H. ;

Savidge, Tor C. ;

Powell, Don W. ;

Liu, Xiaowei ;

Li, Qingjie .

FRONTIERS IN IMMUNOLOGY, 2022, 13

← 1 →