BENDing with Polycomb in pluripotency and cancer

被引：1

作者：

Khan, Abid ^{[1
]}

Prasanth, Supriya ^{[2
,3
]}

机构：

[1] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

[2] Univ Illinois, Dept Cell & Dev Biol, Urbana, IL 61801 USA

[3] UIUC, Canc Ctr Illinois, Chicago, IL USA

来源：

BIOESSAYS | 2023年 / 45卷 / 08期

关键词：

BEND3; PRC2; EZH2; stem cells; pluripotency; BEN-DOMAIN; DNA-BINDING; MECHANISMS;

D O I：

10.1002/bies.202300046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three recent publications on BEND3 firmly establish its role as a novel sequence-specific transcription factor that is essential for PRC2 recruitment and maintenance of pluripotency. Here, we briefly review our current understanding of the BEND3-PRC2 axis in the regulation of pluripotency and also explore the possibility of a similar connection in cancer.

引用

页数：5

共 14 条

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