Clinical characteristics and disease course before and after SARS-CoV-2 infection in a large cohort of systemic sclerosis patients

被引：1

作者：

Guler, Aslihan Avanoglu ^{[1
]}

Ozcimen, Busra ^{[2
]}

Aydogdu, Mesude Seda ^{[3
]}

Sari, Alper ^{[4
]}

Numune, Aliyeva ^{[5
]}

Ersan, Nazife Tuzun ^{[6
]}

Colak, Seda ^{[7
]}

Karadeniz, Hazan ^{[1
]}

Vasi, Ibrahim ^{[1
]}

Kucuk, Hamit ^{[1
]}

Yalcinkaya, Yasemin ^{[5
]}

Erden, Abduelsamet ^{[1
]}

Kayaalp, Mehmet ^{[8
]}

Ozturk, Mehmet Akif ^{[1
]}

Goker, Berna ^{[1
]}

Omma, Ahmet ^{[9
]}

Yilmaz, Sedat ^{[7
]}

Koca, Sueleyman Serdar ^{[3
]}

Inanc, Murat ^{[5
]}

Akdogan, Ali ^{[10
]}

Tufan, Abdurrahman ^{[1
,11
]}

机构：

[1] Gazi Univ, Fac Med, Dept Internal Med, Div Rheumatol, Ankara, Turkiye

[2] Hacettepe Univ, Fac Med, Dept Internal Med, Ankara, Turkiye

[3] Firat Univ, Fac Med, Dept Internal Med, Div Rheumatol, Elazig, Turkiye

[4] Etlik City Hosp, Dept Rheumatol, Ankara, Turkiye

[5] Istanbul Univ, Fac Med, Dept Internal Med, Div Rheumatol, Istanbul, Turkiye

[6] Gazi Univ Hosp, Dept Internal Med, Ankara, Turkiye

[7] Univ Hlth Sci, Gulhane Training & Res Hosp, Dept Rheumatol, Ankara, Turkiye

[8] Yildirim Beyazit Univ, Dept Internal Med, Ankara, Turkiye

[9] Hlth Sci Univ, Ankara City Hosp, Dept Rheumatol, Ankara, Turkiye

[10] Hacettepe Univ, Fac Med, Dept Internal Med, Div Rheumatol, Ankara, Turkiye

[11] NHGRI, Inflammatory Dis Sect, Bethesda, MD 20892 USA

来源：

TURKISH JOURNAL OF MEDICAL SCIENCES | 2024年 / 54卷 / 01期

关键词：

Systemic sclerosis; COVID-19; interstitial lung disease; outcome; respiratory support;

D O I：

10.55730/1300-0144.5768

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/aim: The objective of this study is to evaluate the clinical presentations and adverse outcomes of Coronavirus Disease 2019 (COVID-19) in patients with systemic sclerosis (SSc) and assess the impact of SSc features on the clinical course of COVID-19. Materials and methods: In this multicenter, retrospective study, SSc patients with COVID-19 were included. Clinical features of SSc, along with detailed COVID-19 data, were extracted from medical records and patient interviews. Results: The study included 112 patients (mean age 51.4 +/- 12.8 years; 90.2% female). SSc-associated interstitial lung disease (ILD) was evident in 57.1% of the patients. The findings revealed hospitalization in 25.5%, respiratory support in 16.3%, intensive care unit admission in 3.6%, and a mortality rate of 2.7% among SSc patients with COVID-19. Risk factors for respiratory failure, identified through univariate analysis, included ILD (OR: 7.49, 95% CI: 1.63-34.46), >= 1 comorbidity (OR: 4.55, 95% CI: 1.39-14.88), a higher physician global assessment score at the last outpatient visit (OR 2.73, 95% CI: 1.22-6.10), and the use of mycophenolate at the time of infection (OR: 5.16, 95 %CI: 1.79-14.99). Notably, >= 1 comorbidity emerged as the sole significant predictor of the need for respiratory support in COVID-19 (OR: 5.78, 95% CI: 1.14-29.23). In the early post-COVID-19 period, 17% of patients reported the progression of the Raynaud phenomenon, and 10.6% developed new digital ulcers. Furthermore, progression or new onset of dyspnea and cough were detected in 28.3% and 11.4% of patients, respectively. Conclusion: This study suggests a potential association between adverse outcomes of COVID-19 and SSc-related ILD, severe disease activity, and the use of mycophenolate. Additionally, it highlights that having comorbidities is an independent risk factor for the need for respiratory support in COVID-19 cases.

引用

页码：76 / 85

页数：12

共 32 条

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