Hormone Replacement Therapy and Psoriasis Risk: A Nationwide Population-Based Cohort Study

被引：5

作者：

Go, Gang Min ^{[1
]}

Oh, Hyun Ju ^{[2
]}

Han, Kyungdo ^{[3
]}

Kim, Yeong Ho ^{[2
]}

Lee, Hyun Ji

Lee, Ji Hyun ^{[2
]}

机构：

[1] Catholic Univ Korea, Dept Dermatol, Yeouido St Marys Hosp, Coll Med, Seoul, South Korea

[2] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Dermatol, 222 Banpo Daero, Seoul 06591, South Korea

[3] Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea

来源：

JOURNAL OF KOREAN MEDICAL SCIENCE | 2023年 / 38卷 / 49期

基金：

新加坡国家研究基金会;

关键词：

Cohort Study; Epidemiological Study; Hormone Replacement Therapy; Psoriasis; Risk Factor; SYSTEMIC-LUPUS-ERYTHEMATOSUS; POSTMENOPAUSAL ESTROGEN; WOMEN; YOUNGER; PRESSURE; RECEPTOR; MARKERS; PROTEIN; EVENTS; BLOOD;

D O I：

10.3346/jkms.2023.38.e377

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Hormone replacement therapy (HRT) is used to relieve menopause symptoms, but has been reported to be associated with coronary heart disease and cancers in women. However, a link between HRT and psoriasis has yet to be established. The aim of this study was to determine the association between HRT and the risk of psoriasis.Methods: We executed a nationwide population-based study. A total of 1,130,741 post-menopause women were enrolled in the national health care insurance database based on the enrollment criteria. The study population was classified into four groups based on the duration of the HRT, and the risk of psoriasis was analyzed.Results: The incidence rates of psoriasis per 1,000 person-years were 3.36 and 4.09 in the no history of HRT and >= 5 years of HRT, respectively. After adjustment for age, smoking, alcohol intake, regular exercise, body mass index, diabetes mellitus, hypertension, and dyslipidemia, the most prolonged duration of the HRT group (>= 5 years) exhibited significantly increased risk of developing psoriasis (hazard ratio, 1.22; 95% confidence interval, 1.16-1.29).Conclusion: We propose that HRT in post-menopausal women is associated with an increased likelihood of psoriasis development.

引用

页数：10

共 45 条

[1] Hormone replacement therapy reduces the reactivity of monocytes and platelets in whole blood - A beneficial effect on atherogenesis and thrombus formation? [J].