Drug Prescriptions Requiring Compounding at a Canadian University Affiliated Pediatric Hospital: A Cross-Sectional Study

被引：1

作者：

Landry, Emilie Kate ^{[1
]}

Autmizguine, Julie ^{[1
,2
,3
]}

Berube, Sophie ^{[1
]}

Kraus, Raphael ^{[1
,2
]}

Metras, Marie-Elaine ^{[4
]}

Lebel, Denis ^{[1
,4
]}

Litalien, Catherine ^{[1
,2
]}

机构：

[1] CHU Sainte Justine, Rosalind & Morris Goodman Family Pediat Formulat C, Montreal, PQ H3T 1C5, Canada

[2] CHU Sainte Justine, Dept Pediat, Montreal, PQ H3T 1C5, Canada

[3] Univ Montreal, Fac Med, Ctr Ville Stn, Dept Pharmacol & Physiol, Montreal, PQ H3C 3J7, Canada

[4] CHU Sainte Justine, Dept Pharm, Montreal, PQ H3T 1C5, Canada

来源：

CHILDREN-BASEL | 2023年 / 10卷 / 01期

关键词：

pediatric formulations; compounded drugs; compounding; hospital pharmacy; liquid oral dosage form; solid oral dosage form; REGULATORY FRAMEWORK; MEDICATIONS; CHILDREN; MEDICINES;

D O I：

10.3390/children10010147

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Despite ongoing international efforts, many drugs administered to children must be compounded from dosage forms designed for adults because they remain unavailable in commercial formulations that suit their needs. Even though oral drug compounding is common in pediatrics, the extent of this practice has not been well described in recent years. This cross-sectional and retrospective study was conducted at a Canadian university-affiliated, 484-bed, tertiary care pediatric hospital and its rehabilitation centre on two randomly selected days. A total of 606 hospitalized children with 5465 prescriptions were included. Overall, compounded drugs for enteral administration (CDEA) represented 13% of all prescriptions (enteral and parenteral) and 23% of prescriptions for enteral administration. Of the 390 prescribed drugs, 122 required compounding. CDEA were mostly liquids (n = 478 [67%]) and mainly included drugs of the central nervous (35%), cardiovascular (21%), and gastro-intestinal (12%) systems. Nearly half (N = 298 [49%]) of children had at least one CDEA prescribed in their medical file. Many CDEA are available as commercial products in other jurisdictions. Collaboration is needed between all stakeholders to make these drugs available to Canadian children.

引用

页数：10

共 19 条

[1]

[Anonymous], 2017, ICH Harmonised Guideline-Addendum to ICH E11: Clinical Investigation of Medicinal Products in the Pediatric Population E11 (R1)

[2] An Algorithm to Identify Compounded Non-Sterile Products that Can Be Formulated on a Commercial Scale or Imported to Promote Safer Medication Use in Children [J].