Polycystic Ovary Syndrome and Oxidative Stress. Natural Treatments

被引:0
|
作者
Motta, Alicia Beatriz [1 ]
机构
[1] Univ Buenos Aires UBA, Ctr Estudios Farmacol & Bot CEFYBO, Consejo Nacl Invest Cient & Tecnol CONICET, Fac Med,Lab Fisiopatol Ovar, Paraguay 2155, RA-1121 Buenos Aires, Argentina
关键词
Polycystic ovary syndrome (PCOS); oxidative stress (OS); insulin resistance (IR); anti- oxidant defenses; metabolic syndrome (MS); beta-carotene; TOTAL ANTIOXIDANT CAPACITY; ANTI-MULLERIAN HORMONE; GLYCATION END-PRODUCTS; IN-VITRO; METABOLIC SYNDROME; CONTROLLED-TRIAL; DOUBLE-BLIND; MELATONIN; SUPPLEMENTATION; MAGNESIUM;
D O I
10.2174/0109298673270372231130071320
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Polycystic ovary syndrome (PCOS) is one of the most frequent endocrinopathology affecting women in their reproductive ages. However, PCOS is also related to metabolic abnormalities such as metabolic syndrome (MS), insulin resistance (IR), and type 2 diabetes, among others. Consequently, an inflammatory and pro-oxidative status is also present in these patients, aggravating the syndrome's symptoms. This work aims to discuss some late treatments that focus on oxidative stress (OS) as a central feature related to primary PCOS abnormalities. Therefore, this review focuses on the evidence of anti-oxidant diets, natural compounds, mineralocorticoids, and combined therapies for PCOS management. Oxidative stress (OS) is important in PCOS pathogenesis. In this regard, increased levels of oxidative oxygen species and decreased levels of anti-oxidant agents' impact PCOS's reproductive and metabolic features. In the last years, non-pharmacological therapies have been considered a first line of treatment. For these reasons, several natural compounds such as Kelult honey (KH), Foeniculum vulgare, Calendula officinalis Linn, Eugenia caryophyllus and Myristicafragrans, vitamin C, vitamin E, selenium, zinc, beta-carotene, magnesium, curcumin, mineralocorticoids and melatonin alone or in combination are powerful anti-oxidant agents being used for PCOS management. Data presented here suggest that natural therapies are essential in managing both reproductive and metabolic features in PCOS patients. Due to the results obtained, these incipient therapies deserve further investigation.
引用
收藏
页码:1457 / 1468
页数:12
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